Mineral profile of Ghanaian dried tobacco leaves and local snuff: A comparative study

Addo, M. A.; Gbadago, J.K.; Affum, H. A.; Adom, Theodosia; Ahmed, Khondoker Shahin; Okley, G. M.

doi:10.1007/s10967-007-7054-x

Cited by 21 publications

(11 citation statements)

References 19 publications

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“…However, Fe and Co concentrations in tobacco in this work are much lower than those previously reported in the literature. Cr toxicity in man has been limited to hemorrhage, respiratory impairment, and liver lesions (Addo et al 2008). The concentration of Cr in tobacco ranged from 3.2 to 7.3 mg g À1 , which is similar to the previously reported levels.…”

Section: Toxicological and Environmental Chemistry 1895supporting

confidence: 86%

Trace metal concentrations in cigarette brands commonly available in Turkey: relation with human health

Duran

Tüzen

Soylak

2012

Toxicological & Environmental Chemistry

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In this study, the concentrations of Co, Ni, Fe, Cu, Mn, Pb, Cr, and Cd were determined in 15 cigarette brands from Turkey by flame atomic absorption spectrometry (FAAS). A wet digestion method was employed to cigarette samples. The mean values obtained for Co, Ni, Fe, Cu, Mn, Pb, Cr, and Cd were 1.2, 4.1, 134, 14, 66, 3.7, 5.0, and 1.1 mg g À1 , respectively, i.e., in the order of Fe > Mn > Cu > Cr > Ni > Pb > Co > Cd. The results were compared with the literature values for other international cigarette brands.

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Section: Toxicological and Environmental Chemistry 1895supporting

confidence: 86%

Trace metal concentrations in cigarette brands commonly available in Turkey: relation with human health

Duran

Tüzen

Soylak

2012

Toxicological & Environmental Chemistry

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“…Acute Cd ingestion can cause gastrointestinal tract erosion, pulmonary, hepatic , depending on the , 57]. The levels of Cd measured in the present study for instance is considered to be high as reported by Addo et al[58] in their study on Mineral profile of Ghanaian dried tobacco leaves and local snuff.Studies have indicated that Hg occurs naturally and contaminates the environment largely as a result of anthropogenic activities. It is a systemic toxicant that induces adverse health effects in humans, including cardiovascular diseases.…”

supporting

confidence: 48%

“…Studies have shown that Cd levels in the blood and urine of cigarette smokers are higher [54,55]. Acute Cd ingestion can cause gastrointestinal tract erosion, pulmonary, hepatic or renal injury and coma, depending on the exposure route of poisoning [56,57 of Cd measured in the present study for instance is considered to be high as reported by Addo et al [58] in their study on Mineral profile of Ghanaian dried tobacco leaves and local snuff…”

Section: Implications Of As CD Hg Pb and Cr Contaminants In Tobaccmentioning

confidence: 56%

Toxic Metal Contamination of Locally Produced Tobacco in Tamale Metropolis in Northern Region of Ghana

Sebiawu¹,

Mensah²,

Amankwah

et al. 2020

CJAST

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The study was to analyze and determine the toxic metal contamination level of locally produced tobacco sold in the Tamale Metropolis of Northern region. The study was carried out at the Tamale Metropolis of Northern region of Ghana within a period of 12 months. The study focused on the analyses of five (5) toxic metal contaminants in twelve (12) variant locally produced tobacco sold in various spots within the Tamale Metropolis of Ghana. Toxic metals including As, Cd, Hg, Pb and Cr were analyzed using Flame Atomic Absorption Spectrophotometer. The mean recorded concentrations of As, Cd, Hg, Pb and Cr were respectively in the ranges of 0.184 ± 0.011 to 0.515 ± 0.015 µg/kg, 0.0420 ± 0.010 to 3.100 ± 0.000 µg/kg, 0.176 ± 0.016 to 0.291 ± 0.009 µg/kg, 1.169 ± 0.019 to 3.195 ± 0.019 µg/kg and 1.600 ± 0.116 to 3.880 ± 0.369 µg/kg. The mean concentrations of As and Pb measured in all samples tested were below their respective WHO permissible limits of 4.00 ppm and 10.00 ppm. In the case of Cd, mean concentrations measured for all locally produced tobacco tested were above the WHO permissible limits of 0.30 ppm. For the metal Hg, levels measured in 75% of tested locally produced tobacco were slightly above the WHO permissible limit of 0.20 µg/kg. Cr levels measured in 30% of tested locally produced tobacco were below the WHO permissible limits of 2.00 µg/kg. The very presence of these metals typically raises health concerns on consumption in the instances where their levels exceeded permissible guideline limits. The study revealed that Cd, Hg and Cr levels in the locally produced tobacco studied were found to exceed the WHO permissible limits for human consumption by plant uptake with As and Pb levels well below their permissible thresholds. The analyzed locally produced tobacco essentially poses a threat of heavy metal toxicity to consumers via bioaccumulation and bio-concentration in human tissues.

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“…The data presented in the Table shows that the mean difference of urea and creatinine are significantly elevated ( p < .001) in the serum of nicotine exposed group as compared to the control group. Earlier studies reported that a progressive kidney failure can be associated with a gradual decrease of renal and nonrenal elimination of nicotine, and this increases the rate of nephrotoxicity (Addo et al, ). Also, the effects of heavy metals in tobacco like Cadmium (Cd), Mercury (Hg), and Lead (Pb), might be the another possible factors for tobacco‐induced renal damage (Usunobun et al, ).…”

Section: Discussionmentioning

confidence: 99%

Potential amelioration of nicotine‐induced toxicity by nanocurcumin

Chattopadhyay

Samanta

Mukhopadhyay

et al. 2018

Drug Development Research

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Clinical Research Curcumin, a nontoxic bioactive agent of turmeric significantly reduces nicotine-induced toxicity both at cellular and genetic levels. The clinical implication of native curcumin is hindered in the target cells due to its low aqueous solubility, poor bioavailability and poor pharmacokinetics. The problem was tried to overcome by preparing nanocurcumin with a view to improve its aqueous solubility and better therapeutic efficacy against nicotine-induced toxicity. The prepared nanocurcumin was characterized by Ultraviolet-visible spectroscopy; Field emission scanning electron microscopy (FE-SEM); X-ray diffraction (XRD); and Fourier transform infrared spectroscopy (FTIR). Female albino rats of Wistar strain were daily exposed to effective dose of nicotine (2.5 mg/kg, injected subcutaneously) and supplemented with effective dose of curcumin (80 mg/kg body weight orally) or nanocurcumin (4 mg/kg body weight orally) for 21 days. The preventive efficacies of curcumin and nanocurcumin were evaluated against the changes in liver function enzymes, kidney function parameters, lipid profiles, lipid-peroxidation, anti-oxidant status, and tissues damages etc. Results revealed that nanocurcumin more effectively ameliorated the nicotine-induced toxicities at much lower concentration due to its higher aqueous solubility and more bioavailability. The nanocurcumin can be used as a potential therapeutic agent for better efficacy against nicotine-induced toxicities than native curcumin.

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Mineral profile of Ghanaian dried tobacco leaves and local snuff: A comparative study

Cited by 21 publications

References 19 publications

Trace metal concentrations in cigarette brands commonly available in Turkey: relation with human health

Trace metal concentrations in cigarette brands commonly available in Turkey: relation with human health

Toxic Metal Contamination of Locally Produced Tobacco in Tamale Metropolis in Northern Region of Ghana

Potential amelioration of nicotine‐induced toxicity by nanocurcumin

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