Mineralization followup with the use of NMR spectroscopy and others

Abstract

High-resolution solid state NMR spectroscopy appears to be a powerful method for a better understanding of bone structures and bone substitutes and implants. It is particularly efficient to estimate osteoformation via bioceramic bone colonization. Pathological calcification occurring in bioprosthetic heart valves and breast prostheses can be characterized as a complement to X-ray spectrometry.

Possibilities of Mechanochemical Synthesis of Apatites with Different Ca/P Ratios

“…The NMR parameters of the observed lines are given in Tables 3 and 4. The line fitting was carried out in accordance with literature data [26][27][28][29][30][31][32]. The signal of phosphate tetrahedra of the HAp phase (δ iso ≈ 2.9 ppm) is not observed in the 31 P NMR spectrum of the sample having Ca/P = 1.25.…”

31P Solid‐State NMR study of the chemical setting process of a dual‐paste injectable brushite cements

“…It is known that X‐ray diffraction does not allow characterizing ill‐crystallized phases and therefore structural information related to such phases cannot be obtained by using solely this method. Quantitative determination of the relative proportions of calcium phosphate species by X‐ray diffraction in composite materials is questionable, as previously reported on not perfectly crystallized material 13–15…”

“…Quantitative determination of the relative proportions of calcium phosphate species by X-ray diffraction in composite materials is questionable, as previously reported on not perfectly crystallized material. [13][14][15] Among the most studied CPCs 16 The objective of this work is to demonstrate, on such CPC, the ability using Solid-State NMR and X-ray to analyze the initial components, to follow the chemical setting process and to determine the constant composition finally obtained.…”

Mineralization at the interface of implants

“…X-ray or electron diffraction analyses 7,33 as well as advanced element mapping measures 65 allow the discrimination between a bone-related, mature or otherwise comprised mineral formation. Advances in imaging 57 and analytical techniques 19,59 allow a more detailed insight into the features of mineral formation at implants. Some of the new techniques additionally enable the combined biochemical and crystallographic analysis of implant probes (TOF-SIMS), important in respect of fully understanding the process of osseointegration.…”