Mineralocorticoid deficiency in HIV infection.

Murphy, Cynthia; Ratnavel, R. G.; Davidson, A C

doi:10.1136/bmj.298.6681.1181-b

Cited by 7 publications

(2 citation statements)

References 1 publication

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“…According to the recent reports on AIDSpatients with Pneumocystis carinii pneumonia, hyperkalemia is recognized in 44 to 70%of patients who are given Tmp-Smxat high doses (6)(7)(8)(13)(14)(15)(16). This hyperkalemia is also supposed to be due to high-dose Tmp-Smx therapy which causes reduced sodium reabsorption and potassium excretion in the distal tubules.…”

Section: Discussionmentioning

confidence: 99%

Severe Hyponatremia and Hyperkalemia Induced by Trimethoprim-Sulfamethoxazole in Patients with Pneumocystis carinii Pneumonia.

et al. 1995

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An antimicrobial agent trimethoprim-sulfamethoxazole (Tmp-Smx)does not usually cause electrolyte disturbances at regular doses, and few cases ofTmp-Smx-inducedelectrolyte imbalance have been reported in the English-language literature to date. Recently, however, we treated two patients with Pneumocystis carinii pneumoniawhodeveloped severe hyponatremia and hyperkalemia on administration of high-dose Tmp-Smx.These electrolyte disturbances were attributable to the direct effect of Tmp-Smxon the renal distal tubules, were reversible, and corrected by infusion of a sodium-enriched and potassium-free liquid. Therefore, it is suggested that even after electrolyte disturbances have occurred, high-dose Tmp-Smxtherapy may be continued for severe infectious diseases under appropriate electrolyte correction. (Internal Medicine 34: 96-99, 1995)

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Section: Discussionmentioning

confidence: 99%

Severe Hyponatremia and Hyperkalemia Induced by Trimethoprim-Sulfamethoxazole in Patients with Pneumocystis carinii Pneumonia.

et al. 1995

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“…A 40-year-old woman with transplanted lungs developed life threatening hyperkalaemia (6.8 mmol L −" ) during high dose treatment with trimethoprim-sulfamethoxazole for Pneumocystis carinii pneumonia. Trimethoprim has an amiloridelike effect on the distal nephron and may thus induce There have been some reports on hyperkalaemia induced by high dose trimethoprim-sulfamethoxazole (Tmp-Smx) therapy for pneumocystis carinii infection in HIV-infected patients [1][2][3][4]. Hyperkalaemia is not associated with the usual doses of Tmp-Smx, and reports on hyperkalaemia induced by high doses in patients without AIDS are few [5][6][7].…”

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confidence: 99%

Severe hyperkalaemia induced by trimethoprim in combination with an angiotensin‐converting enzyme inhibitor in a patient with transplanted lungs

Bugge

1996

Journal of Internal Medicine

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A 40-year-old woman with transplanted lungs developed life threatening hyperkalaemia (6.8 mmol L-1) during high dose treatment with trimethoprim-sulfamethoxazole for Pneumocystis carinii pneumonia. Trimethoprim has an amiloride-like effect on the distal nephron and may thus induce hyperkalaemia, particularly if other contributing factors coexist. The present patient was also treated with the angiotensin-converting enzyme (ACE) inhibitor enalapril, and the combination of ACE-inhibition and potassium-sparing diuretics is known to induce hyperkalaemia. Hyperkalaemia was probably induced by the combination of ACE-inhibitor and trimethoprim, and this combination may be as dangerous as the combination of ACE-inhibitors with other potassium-sparing diuretics.

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Sulfonamides, sulfadiazine, trimethoprim-sulfamethoxazole, pentamidine, pyrimethamine, dapsone, quinolones

Vaamonde¹,

Contreras²,

Diego³

2003

Clinical Nephrotoxins

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Mineralocorticoid deficiency in HIV infection.

Cited by 7 publications

References 1 publication

Severe Hyponatremia and Hyperkalemia Induced by Trimethoprim-Sulfamethoxazole in Patients with Pneumocystis carinii Pneumonia.

Severe Hyponatremia and Hyperkalemia Induced by Trimethoprim-Sulfamethoxazole in Patients with Pneumocystis carinii Pneumonia.

Severe hyperkalaemia induced by trimethoprim in combination with an angiotensin‐converting enzyme inhibitor in a patient with transplanted lungs

Sulfonamides, sulfadiazine, trimethoprim-sulfamethoxazole, pentamidine, pyrimethamine, dapsone, quinolones

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