Mineralocorticoid receptor antagonists: new extended roles in cardio- and nephroprotection

Есаян, А. М.; Нимгирова, А. Н.

doi:10.21518/2079-701x-2018-5-58-63

Cited by 1 publication

(3 citation statements)

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“…CKD is diagnosed in the presence of kidney injury and/or decreased glomerular filtration that persists for three or more months [2,3]. Kidney damage is diagnosed in case of any manifestation of pathological albuminuria/protheinuria, pathological urine precipitate, histological signs of kidney damage, presence of pathology based on X-ray diagnostics results [3]. In CKD the glomerular filtration rate decrease is less than 60 ml/min/1.73 m 2 [2,3] and it is the main marker of this pathological state.…”

Section: Introductionmentioning

confidence: 99%

“…Kidney damage is diagnosed in case of any manifestation of pathological albuminuria/protheinuria, pathological urine precipitate, histological signs of kidney damage, presence of pathology based on X-ray diagnostics results [3]. In CKD the glomerular filtration rate decrease is less than 60 ml/min/1.73 m 2 [2,3] and it is the main marker of this pathological state. The CKD stage is estimated by the calculated glomerular filtration rate [3].…”

Section: Introductionmentioning

confidence: 99%

“…In CKD the glomerular filtration rate decrease is less than 60 ml/min/1.73 m 2 [2,3] and it is the main marker of this pathological state. The CKD stage is estimated by the calculated glomerular filtration rate [3]. Chronic kidney disease is recognized as a risk factor for cardiovascular disease (CVD) along with other factors as arterial hypertension, diabetes mellitus and dyslipidemia [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Pathogenetic Subtypes and Ischemic Stroke Outcomes in Patients with Chronic Kidney Disease

Chugunova¹,

Egorova²

2022

Proceedings of the Conference on Health and Wellbeing in Modern Society (CHW 2021)

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A study has been conducted to investigate the relationships between the risk of developing various pathogenetic subtypes of ischemic stroke (IS) and its outcomes with chronic kidney disease (CKD). A retrospective study was conducted in the group of IS patients (n=1070): with CKD (n=343) and without CKD (n=727). TOAST classification was used to determine IS subtypes. The study data showed that in patients with CKD compared to patients without CKD, TOAST2 frequency was more common in total group (p<0.0001; OR=1.878 (1.423-2.478)), among men (p<0.001; OR=2.008 (1.370-2.943)) and among women (p=0.009; OR=1.720 (1.145-2.584)); TOAST1 frequency was rare in total group (p<0.0001; OR=0.565 (0.435-0.734)), among men (p<0.0001; OR=0.502 (0.353-0.713)) and among women (p=0.042; OR=0.665 (0.448-0.487)); stroke manifestations were more severe an NIHSS scale (p=0.0001), Glasgow coma scale (p=0.002); IS mortality was higher (13.7 % versus 7.4 %; p=0.001;) in total group and TOAST2 mortality was higher (25.0 % vs.14.9 %; p=0.027; OR=1.910 (1.072-3.404) in total group and among women (29.7 % versus 11.1 %; p=0.004; )). Conclusions. IS patients with CKD are more likely to develop cardioembolic stroke (p<0.0001; OR=1.878 (1.423-2.478)), have more severe stroke manifestations (NIHSS score, p=0.0001; Glasgow score, p=0.002), have higher cardioembolic stroke mortality among women (29.7 % versus 11.1 %; p=0.004;) compared to IS patients without CKD.

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Section: Introductionmentioning

confidence: 99%