2024
DOI: 10.62347/mnya9065
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Mineralocorticoid receptor signaling inhibits bladder cancer progression

Yujiro Nagata

Abstract: The biological or clinical significance of mineralocorticoid receptor (MR) in urothelial cancer remains largely unknown. The present study aimed to determine the functional role of MR in bladder cancer progression. In two of the human bladder cancer lines expressing MR, treatment with a natural MR ligand, aldosterone, significantly reduced cell proliferation and migration, which was restored by three MR antagonists clinically used, spironolactone (except colony formation of androgen receptor-positive cells cul… Show more

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Cited by 2 publications
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