Mini-dose of thalidomide for treatment of primary myelofibrosis. Report of a case with complete reversal of bone marrow fibrosis and splenomegaly

Berrébi, Alain; Feldberg, Edit; Spivak, Irena; Shvidel, Lev

doi:10.3324/haematol.10684

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Cited by 7 publications

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“…The main adverse effects of thalidomide are sedation, fatigue, constipation, peripheral neuropathy and thromboembolic phenomena; however, thalidomide treatment was well tolerated in the present patient (19).…”

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confidence: 39%

Cutaneous and systemic plasmacytosis on the face: Effective treatment of a case using thalidomide

2016

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Abstract. Cutaneous and systemic plasmacytosis is an exceedingly rare condition that is identified in Japanese individuals in particular. The present study describes the case of a patient of mainland Chinese origin who manifested with red-brown macules, papules and plaques limited to the face. Identifying a therapy for cutaneous and systemic plasmacytosis is quite difficult, however, the present patient showed a good response to low-dose thalidomide. The exact mechanism of action is not yet clear, however, we hypothesize that thalidomide may function through decreasing the secretion of interleukin-6 and affecting the growth of plasma cells.

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confidence: 39%