Carpal tunnel syndrome (CTS) is the most common compression neuropathy of the upper extremity, which develops as a result of compression of median nerve at the level of wrist. [1] The ideal surgical decompression method remains controversial and has inspired less invasive techniques such as endoscopy-assisted tunnel release (ECTR) and ultrasound-guided methods. While there are many purported advantages of ECTR, such as better patient comfort and early recovery period, ECTR and open approaches have similar long-term outcomes. [2] The classical approach of decompression is open release of the carpal tunnel. Phalen [3] first reported his experience and results of open carpal tunnel surgery in 1966. The classical surgical incision of the open carpal tunnel surgery extends from Kaplan's cardinal line (KCL) to wrist crease. This extended technique prevents inadequate decompression by visualization of the surgical site both proximally and distally. However, many surgeons favor shorter incisions due to unsettling scar formation after extended approach. Also, the mini-open technique has been shown to produce lower recurrence and shorter recovery period with obvious reduction in pain and Objectives: This study aims to describe a retrospective study using prospectively gathered data to compare mini-open and extended open release techniques for moderate to severe carpal tunnel syndrome (CTS). Patients and methods: The data of 198 consecutive patients (139 males, 59 females; mean age 57.0±4.5 years; range, 44 to 75 years) treated for CPS were used. For matching, age, gender and severity of the compression, the Greathouse Ernst Halle Schaffer neurophysiological classification system was used. After matching, 63 observations in each group (group 1: mini-open and group 2: extended open) were used for analysis. A Jamar hydraulic hand dynamometer was used to measure preand postoperative third month grip strengths. The key pinch test was performed also at third month. Patients completed the Boston Carpal Tunnel Questionnaire at the last follow-up. Results: Symptom severity and functional status were improved up to half fold in both groups at final follow-up; however, there was no statistically significant clinical difference between the groups (p>0.05). There were totally six patients with paresthesia symptoms (three in each group; 4.7%), which improved in three months. Eight patients (6.3%, one in group 1 and seven in group 2, p=0.032) had dysesthesia and pillar pain. Conclusion: Mini-open and extended open carpal tunnel release have similar clinical outcomes without any major complications.