Mini-review: Lactoferrin: a bioinspired, anti-biofilm therapeutic

Abstract

Medically relevant biofilms have gained a significant level of interest, in part because of the epidemic rise in obesity and an aging population in the developed world. The associated comorbidities of chronic wounds such as pressure ulcers, venous leg ulcers, and diabetic foot wounds remain recalcitrant to the therapies available currently. Development of chronicity in the wound is due primarily to an inability to complete the wound healing process owing to the presence of a bioburden, specifically bacterial biofilms. New therapies are clearly needed which specifically target biofilms. Lactoferrin is a multifaceted molecule of the innate immune system found primarily in milk. While further investigation is warranted to elucidate mechanisms of action, in vitro analyses of lactoferrin and its derivatives have demonstrated that these complex molecules are structurally and functionally well suited to address the heterogeneity of bacterial biofilms. In addition, use of lactoferrin and its derivatives has proven promising in the clinic.

Evaluation of cationic micropeptides derived from the innate immune system as inhibitors of marine biofouling

“…The current research offers a relevant comparison for further studies into the underlying mechanisms (Hanssen et al 2014;Trepos et al 2014). The current investigation represents the first study of the effects of compounds initially derived from the innate immune system on marine biofouling and on organisms in a marine setting, and extends recent studies towards biofilms (Ammons & Copie 2013;Alves & Olivia Pereira 2014). The complex biofouling scenario, in which several types of organisms are involved, is difficult to mimic in a single assay (Bernbom et al 2013) and it is necessary to include both micro-and macrofoulers in a study when assessing the complete potential AF properties of a compound (Qian et al 2010).…”

Injuries in Thai Boxing

“…Thanks to its chelating properties, LF can reduce the indirect effects of reactive oxygen species at inflammation sites and thus protects the tissue against damage (Ward et al, 2005). Infection results in neutrophil degranulation, and LF released from their specific granules has the ability to quickly inactivate LPS, thereby protecting the tissue against damage (Baveye, Elass, Mazurier, Legrand, 2000;Ammons, Copié, 2013). Anti-inflammatory properties of LF have also been confirmed by in vivo tests in animal models.…”

Медикаментозне Обмеження Доступності Іонів Заліза Для Патогенних Бактерій (Частина 1)

“…Антипленочная активность LTF наблюдается даже при очень низ-кой его концентрации (0,02 мг/мл). Прямое по-давление роста бактерий наблюдается при значи-тельно более высоких концентрациях LTF (выше в пять и более раз) [1,4,16]. Piera Valenti и соавт.…”