Mini-Review on the Implications of Gene Polymorphism in the Metabolism of Xenobiotics

LUCA, ALINA-COSTINA

doi:10.31925/farmacia.2022.4.1

Cited by 2 publications

(1 citation statement)

References 80 publications

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“…Even so, exposome evaluation needs are still not fully covered by available technologies. According to the previous study, the amount of environmental chemicals in biological samples is 3 -4 orders of magnitude lower, on average, than that of endogenous metabolites, drugs, or food constituents [49,65]. Thus, going beyond the metabolome level and moving into the exposome requires use of more sensitive tools or methods.…”

Section: Sensors For Environmental or Personal Monitoringmentioning

confidence: 99%

Exposome Research: Definition, Scope and the Need for Multidisciplinary Research

NEGREI

2023

FARMACIA

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Mentioned for the first time in 2005, the exposome concept initially emerged in response to the need to reflect in research the significant impact of the environment on health and disease. Since its emergence, in line with the rapid developments in general knowledge and technology, as well as with the dramatic changes in geoclimatic conditions, the notion has been in remarkable progress. Originally meant as a call for the development of more complex methods of environmental exposure assessment, applicable at individual level and throughout the individual's life span, the scope of the concept has now been expanded to also incorporate the associated biological response. In result of over 15 years of research and evolution, exposomics now involves adopting a global and multidisciplinary approach meant to integrate and develop the top-down, bottom-up and functional study strategies already established in the field, as well as their complementation with other methods, increasing efforts for their standardization and validation, thus rendering exposomics increased utility in clinical practice. This review is focused on the introduction of the exposome concept and the development of research from its perspective that can only be achieved under the conditions of multidisciplinary collaboration, with the participation of scientific fields such as environment, social sciences, analytical chemistry, molecular biology, toxicology, epidemiology and medicine. RezumatMenționat pentru prima dată în 2005, conceptul de expozom a apărut inițial ca răspuns la nevoia de a reflecta asupra impactului semnificativ al mediului asupra sănătății și bolii. De la apariția sa, în concordanță cu evoluțiile rapide ale cunoștințelor generale și ale tehnologiei, precum și cu schimbările dramatice ale condițiilor geoclimatice, noțiunea a cunoscut un progres remarcabil. Înțeles inițial ca un apel pentru dezvoltarea unor metode mai complexe de evaluare a expunerii la mediu, aplicabile la nivel individual și pe toată durata de viață a individului, domeniul de aplicare a conceptului a fost acum extins pentru a include și răspunsul biologic asociat. După 15 ani de cercetare și evoluție, expozomica presupune acum adoptarea unei abordări globale și multidisciplinare menite să integreze și să dezvolte strategiile de studiu după metodele top-down, bottom-up și cele funcționale deja stabilite în domeniu, dar și să le completeze cu alte metode, sporind eforturile de standardizare și validare a acestora și dând astfel expozomicii o utilitate sporită în practica clinică. Această lucrare se concentrează pe introducerea conceptului de expozom și dezvoltarea cercetării din perspectiva acestui concept, care poate fi realizată numai în condițiile unei colaborări multidisciplinare, din mai multe domenii științifice precum mediul, științele sociale, chimia analitică, biologia moleculară, toxicologia, epidemiologia și medicina.

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Section: Sensors For Environmental or Personal Monitoringmentioning

confidence: 99%

Exposome Research: Definition, Scope and the Need for Multidisciplinary Research

NEGREI

2023

FARMACIA

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Drug–Drug Interactions in Nosocomial Infections: An Updated Review for Clinicians

Hîncu,

Apetroaei,

Ștefan

et al. 2024

Pharmaceutics

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Prevention, assessment, and identification of drug–drug interactions (DDIs) represent a challenge for healthcare professionals, especially in nosocomial settings. This narrative review aims to provide a thorough assessment of the most clinically significant DDIs for antibiotics used in healthcare-associated infections. Complex poly-pharmaceutical regimens, targeting multiple pathogens or targeting one pathogen in the presence of another comorbidity, have an increased predisposition to result in life-threatening DDIs. Recognising, assessing, and limiting DDIs in nosocomial infections offers promising opportunities for improving health outcomes. The objective of this review is to provide clinicians with practical advice to prevent or mitigate DDIs, with the aim of increasing the safety and effectiveness of therapy. DDI management is of significant importance for individualising therapy according to the patient, disease status, and associated comorbidities.

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Mini-Review on the Implications of Gene Polymorphism in the Metabolism of Xenobiotics

Cited by 2 publications

References 80 publications

Exposome Research: Definition, Scope and the Need for Multidisciplinary Research

Exposome Research: Definition, Scope and the Need for Multidisciplinary Research

Drug–Drug Interactions in Nosocomial Infections: An Updated Review for Clinicians

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