Mini-review on the psychiatric comorbidities in epilepsy – possible relevance for some metabolic changes?

Abstract

Epilepsy is one of the most important neurological disorders nowadays, with a variety of studies describing its mechanisms and complex pathophysiology. However, lately there is also an increased interest in understanding the psychiatric comorbities associated with the epileptic pathology. Thus, we will describe here aspects such as the importance of anxiety, depression, personality disorders, the suicidal ideation in epilepsy, as well as the correlations that might exist between the specific treatment for epilepsy and its psychiatric-related effects. In conclusion, it seems that the associated psychiatric manifestations from epilepsy have an increased important in the pathophysiology of this disorder and deserve further investigation.