Mini-Review: Recent Advances in Aptamer Applications

Zon, Gerald

doi:10.29245/2578-2967/2020/3.1186

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…Aptamers attached to various nanoparticles seem very promising for the treatment and diagnosis of various diseases [39]. However, FDA has approved no aptamers after Macugen.…”

Section: Discussionmentioning

confidence: 99%

Aptamer Functionalized Liposomes for Cancer Treatment

Danila

2022

AIR

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Cancer is a common disease affecting many people. It is considered that 1 out of 3 people will be diagnosed with cancer in the course of their lives. The current treatments for different types of cancers are conventional radiation and chemotherapy. However, their use becomes limited due to the adverse side effects caused by using overwhelming amounts of radiation or drugs. Targeted drugs look promising since they can reduce the required dose by orders of magnitude and minimize the damage done to normal cells. Targeting the cancer cells is accomplished by using targeted delivery vehicles that specifically recognize the affected cells. The vehicles are functionalized by coupling ligands such as antibodies, peptide, or aptamers. This review paper describes the main FDA approved or in clinical trials formulations of liposomes, aptamers, and aptamer-liposomes. Aptamer-liposomes seem to be very attractive systems for the delivery of drugs for the treatment of various types of cancer.

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“…Aptamers attached to various nanoparticles seem very promising for the treatment and diagnosis of various diseases [39]. However, FDA has approved no aptamers after Macugen.…”

Section: Discussionmentioning

confidence: 99%

Aptamer Functionalized Liposomes for Cancer Treatment

Danila

2022

AIR

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“…[31,32] Some reports propose the use of 𝜋-stacking with different molecules based on pyrene linkers, that have been employed for the functionalization of gSGFETs. [33][34][35] Regarding the biorecognition molecule, the use of aptamers, negatively charged oligonucleotides, has gained interest due to its high affinity and specificity to structurally similar targets, robustness, thermal stability, and non-immunogenicity [36][37][38] that have been combined with graphene-based FETs in different works. [39,40] In addition, aptamers can be functionalized with a large variety of ligands based on robust solid-phase phosphoramidite chemistry, which permits the introduction of different terminal groups to interact with graphene.…”

Section: Introductionmentioning

confidence: 99%

Single‐Step Functionalization Strategy of Graphene Microtransistor Array with Chemically Modified Aptamers for Biosensing Applications

Brosel‐Oliu,

Rius,

Aviñó

et al. 2023

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Graphene solution‐gated field‐effect transistors (gSGFETs) offer high potential for chemical and biochemical sensing applications. Among the current trends to improve this technology, the functionalization processes are gaining relevance for its crucial impact on biosensing performance. Previous efforts are focused on simplifying the attachment procedure from standard multi‐step to single‐step strategies, but they still suffer from overreaction, and impurity issues and are limited to a particular ligand. Herein, a novel strategy for single‐step immobilization of chemically modified aptamers with fluorenylmethyl and acridine moieties, based on a straightforward synthetic route to overcome the aforementioned limitations is presented. This approach is benchmarked versus a standard multi‐step strategy using thrombin as detection model. In order to assess the reliability of the functionalization strategies 48‐gSGFETs arrays are employed to acquire large datasets with multiple replicas. Graphene surface characterization demonstrates robust and higher efficiency in the chemical coupling of the aptamers with the single‐step strategy, while the electrical response evaluation validates the sensing capability, allowing to implement different alternatives for data analysis and reduce the sensing variability. In this work, a new tool capable of overcome the functionalization challenges of graphene surfaces is provided, paving the way toward the standardization of gSGFETs for biosensing purposes.

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Advanced cancer targeting using aptamer functionalized nanocarriers for site-specific cargo delivery

Narwade¹,

Shaikh

Gajbhiye³

et al. 2023

Biomater Res

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The non-specificity of standard anticancer therapies has profound detrimental consequences in clinical treatment. Therapeutic specificity can be precisely achieved using cutting-edge ligands. Small synthetic oligonucleotide-ligands chosen through Systematic evolution of ligands by exponential enrichment (SELEX) would be an unceasing innovation in using nucleic acids as aptamers, frequently referred to as "chemical antibodies.” Aptamers act as externally controlled switching materials that can attach to various substrates, for example, membrane proteins or nucleic acid structures. Aptamers pose excellent specificity and affinity for target molecules and can be used as medicines to suppress tumor cell growth directly. The creation of aptamer-conjugated nanoconstructs has recently opened up innovative options in cancer therapy that are more effective and target tumor cells with minor toxicity to healthy tissues. This review focuses on a comprehensive description of the most capable classes of aptamer-tethered nanocarriers for precise recognition of cancer cells with significant development in proficiency, selectivity, and targetability for cancer therapy. Existing theranostic applications with the problems and future directions are also highlighted. Graphical Abstract

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Mini-Review: Recent Advances in Aptamer Applications

Abstract: Aptamers, which are short strands of synthetic DNA or RNA selected for binding to target ligands, have proven useful for cell-specific delivery, detection, or both. This mini-review presents selected examples of these applications for cancer published during 2019 – September 2020.

Cited by 3 publications

References 34 publications

Aptamer Functionalized Liposomes for Cancer Treatment

Aptamer Functionalized Liposomes for Cancer Treatment

Single‐Step Functionalization Strategy of Graphene Microtransistor Array with Chemically Modified Aptamers for Biosensing Applications

Advanced cancer targeting using aptamer functionalized nanocarriers for site-specific cargo delivery

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