Mini-tablets versus pellets as promising multiparticulate modified release delivery systems for highly soluble drugs

Feasibility of mini-tablets as a flexible drug delivery tool

“…Currently, mini-tablet products are classified as multi-particulates, granules or sprinkles; and developed as capsules, sachets, or stick pack dosage forms for immediate release (Efentakis et al, 2000), extended and sustained release (Efentakis et al, 2000;Munday and Fassihi, 1989;Roberts et al, 2012), biphasic release (Filho et al, 2014;Lopes et al, 2006), or controlled release (Gaber et al, 2015). Some commercially available products include Orfiril Long 1 , Levetiracetam Desitin 1 , and Lamisil 1 .…”

Prolonged-release minitablets with carbamazepine – preliminary observations in vitro

“…Actually, minitablets are an ‘intermediate’ formulation, between pellets and tablets, although from the regulatory point of view they are considered as tablets. In comparison with standard size tablets, the minitablets used as MUDFs pose a lower risk of dose dumping and become independent from the stomach emptying frequency . Thus, probably both methods, the coating or the incorporation into a slowly dissolving matrix, can be taken into consideration when the prolonged‐release minitablets are formulated.…”

New aspects of controlled release systems for local anaesthetics: A review

“…For a controlled release vehicle to be viable, it must meet a number of requirements such as selectivity, bioavailability and biodegradability [15,26,27]. …”

“…Controlled release systems are systems capable of delivering a biologically active substance from a polymer network in a biological system over a longer period of time [15].…”