Miniature nuclear magnetic resonance spectrometer using a partially enclosed permanent magnet

Lu, Rongsheng; Zhou, Xinlong; Yin, Qifeng; Hu, Jianxiong; Zhang, Ni

doi:10.1080/10739149.2016.1219366

Cited by 5 publications

(3 citation statements)

References 33 publications

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“…17 This makes the study of influence of reaction parameters on relaxivity and their optimization cumbersome. In recent years a variety of miniaturized nuclear magnetic resonance (NMR) relaxometers 18 and even spectrometers 19 have been reported. They show an excellent performance in terms of sensitivity and reliability and possess the advantage of small sample volumes and low costs.…”

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confidence: 99%

Microfluidic-Based Synthesis of Magnetic Nanoparticles Coupled with Miniaturized NMR for Online Relaxation Studies

et al. 2018

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Using compact desktop NMR systems for rapid characterization of relaxation properties directly after synthesis can expedite the development of functional magnetic nanoparticles. Therefore, an automated system that combines a miniaturized NMR relaxometer and a flow-based microreactor for online synthesis and characterization of magnetic iron oxide nanoparticles is constructed and tested. NMR relaxation properties are quantified online with a 0.5 T permanent magnet for measurement of transverse ( T) and longitudinal ( T) relaxation times. Nanoparticles with a primary particle size of about 25 nm are prepared by coprecipitation in a tape-based microreactor that utilizes 3D hydrodynamic flow focusing to avoid channel clogging. Cluster sizes are expeditiously optimized for maximum transverse relaxivity of 115.5 mM s. The compact process control system is an efficient tool that speeds up synthesis optimization and product characterization of magnetic nanoparticles for nanomedical, theranostic, and NMR-based biosensing applications.

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confidence: 99%

Microfluidic-Based Synthesis of Magnetic Nanoparticles Coupled with Miniaturized NMR for Online Relaxation Studies

et al. 2018

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“…However, more efforts need to be taken to simplify the setup of such platforms and data analysis platforms. Simultaneously, analytical platforms are constantly being developed for increased sensitivity to enable detection of metabolites at lower concentrations (Figure 1), increased consistency of detection and reproducibility, while decreasing the physical size of the instruments [107,108,109,110]. A good example is NMR.…”

Section: Translational Challenges In Metabolomicsmentioning

confidence: 99%

“…However, its shortfall lies in sensitivity of detection which can cover a limited scope of metabolites with higher abundance (Figure 1). MS and NMR instruments have evolved over time to become smaller in size and better in detection [108,109]. As these developments continue it will become increasingly easy to solve difficult metabolic problems with increasing translational opportunities.…”

Section: Translational Challenges In Metabolomicsmentioning

confidence: 99%

Translational Metabolomics: Current Challenges and Future Opportunities

Pinu

Goldansaz

Jaine³

2019

Metabolites

157

111

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Metabolomics is one of the latest omics technologies that has been applied successfully in many areas of life sciences. Despite being relatively new, a plethora of publications over the years have exploited the opportunities provided through this data and question driven approach. Most importantly, metabolomics studies have produced great breakthroughs in biomarker discovery, identification of novel metabolites and more detailed characterisation of biological pathways in many organisms. However, translation of the research outcomes into clinical tests and user-friendly interfaces has been hindered due to many factors, some of which have been outlined hereafter. This position paper is the summary of discussion on translational metabolomics undertaken during a peer session of the Australian and New Zealand Metabolomics Conference (ANZMET 2018) held in Auckland, New Zealand. Here, we discuss some of the key areas in translational metabolomics including existing challenges and suggested solutions, as well as how to expand the clinical and industrial application of metabolomics. In addition, we share our perspective on how full translational capability of metabolomics research can be explored.

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Low-field nuclear magnetic resonance spectrometer for non-invasive monitoring of fluctuations in blood glucose in the human finger

Chen

et al. 2018

Spectroscopy Letters

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Miniature nuclear magnetic resonance spectrometer using a partially enclosed permanent magnet

Cited by 5 publications

References 33 publications

Microfluidic-Based Synthesis of Magnetic Nanoparticles Coupled with Miniaturized NMR for Online Relaxation Studies

Microfluidic-Based Synthesis of Magnetic Nanoparticles Coupled with Miniaturized NMR for Online Relaxation Studies

Translational Metabolomics: Current Challenges and Future Opportunities

Low-field nuclear magnetic resonance spectrometer for non-invasive monitoring of fluctuations in blood glucose in the human finger

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