Miniaturizable Ion-Selective Arrays Based on Highly Stable Polymer Membranes for Biomedical Applications

Mir, Mònica; Lugo, Roberto; Tahirbegi, Islam Bogachan; Samitier, J.

doi:10.3390/s140711844

Cited by 29 publications

(15 citation statements)

References 21 publications

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“…In ion-selective sensors, formation of a thin aqueous layer between the sensing membrane and underlying conductive electrode can cause changes in effective compositions of the sensor stack itself over time, producing potential drifts 74 . Adding hydrophobic chemical species can minimize this effect, while electrochemically depositing conducting polymers such as polystyrene, polypyrrole, and polyaniline further improve stability 75,76 . Drift issues also afflict enzymatic sensors.…”

Section: Stabilitymentioning

confidence: 99%

Wearable sweat sensors

2018

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Sweat may contain a wealth of physiologically relevant information but has traditionally been an underutilized resource for non-invasive health monitoring. Recent advancements in wearable sweat sensors have overcome many of the historic drawbacks of sweat sensing and offer new methods of gleaning molecular-level insight into the dynamics of our bodies. Here we review key developments in sweat sensing technology. We highlight the potential value of sweat-based wearable sensors, examine state-ofthe-art devices and requirements of the underlying components, and consider ways to tackle data integrity issues within these systems. We also discuss challenges and opportunities for wearable sweat sensors in the development of personalized healthcare.

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Section: Stabilitymentioning

confidence: 99%

Wearable sweat sensors

2018

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“…The importance of a MWCNTs solid-contact layer is demonstrated by Figure 7. Interferences from O 2 and CO 2 have been reported from several SC-ISEs where gases can easily permeate through the polymeric membrane and cause disturbances at the surface of the Au substrate [15,16]. More specifically, O 2 can form an oxygen half-cell affecting the phase boundary potential, while CO 2 can change the local pH at the electrode surface [49].…”

Section: Resultsmentioning

confidence: 99%

“…The introduction of conducting polymers (CP) as ion-to-electron transducers experienced rapid growth owing to the advantages of the obtained sensor and outstanding performances, which were comparable to those of traditional liquid-contact electrodes in all aspects [13,14]. Some CP-based SC-ISEs have exhibited some problems with water layer formation and interference from gases or light [15,16,17]. The lower detection limit was much worse when the potentiometric water layer test was positive.…”

Section: Introductionmentioning

confidence: 99%

Disposable Multi-Walled Carbon Nanotubes-Based Plasticizer-Free Solid-Contact Pb2+-Selective Electrodes with a Sub-PPB Detection Limit †

Liu

Gao

Yan

et al. 2019

Sensors

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Potentiometric plasticizer-free solid-contact Pb2+-selective electrodes based on copolymer methyl methacrylate-n-butyl acrylate (MMA-BA) as membrane matrix and multi-walled carbon nanotubes (MWCNTs) as intermediate ion-to-electron transducing layer have been developed. The disposable electrodes were prepared by drop-casting the copolymer membrane onto a layer of MWCNTs, which deposited on golden disk electrodes. The obtained electrodes exhibited a sub-ppb level detection limit of 10−10 mol·L−1. The proposed electrodes demonstrated a Nernstian slope of 29.1 ± 0.5 mV/decade in the linear range from 2.0 × 10−10 to 1.5 × 10−3 mol·L−1. No interference from gases (O2 and CO2) or water films was observed. The electrochemical impedance spectroscopy of the fabricated electrodes was compared to that of plasticizer-free Pb2+-selective electrodes without MWCNTs as intermediated layers. The plasticizer-free MWCNTs-based Pb2+-selective electrodes can provide a promising platform for Pb(II) detection in environmental and clinical application.

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“…(B) Schematic drawing of ion-selective membrane for potassium detection. Reproduced with permission from ref ( 61 ). Copyright 2014 The Authors under Creative Commons Attribution 3.0 Unported License, published by MCPI.…”

Section: Future Oportunities For the Integration Of Biosensors In Bbb-ocmentioning

confidence: 99%

Biosensors Integration in Blood–Brain Barrier-on-a-Chip: Emerging Platform for Monitoring Neurodegenerative Diseases

et al. 2022

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Over the most recent decades, the development of new biological platforms to study disease progression and drug efficacy has been of great interest due to the high increase in the rate of neurodegenerative diseases (NDDs). Therefore, blood–brain barrier (BBB) as an organ-on-a-chip (OoC) platform to mimic brain-barrier performance could offer a deeper understanding of NDDs as well as a very valuable tool for drug permeability testing for new treatments. A very attractive improvement of BBB-oC technology is the integration of detection systems to provide continuous monitoring of biomarkers in real time and a fully automated analysis of drug permeably, rendering more efficient platforms for commercialization. In this Perspective, an overview of the main BBB-oC configurations is introduced and a critical vision of the BBB-oC platforms integrating electronic read out systems is detailed, indicating the strengths and weaknesses of current devices, proposing the great potential for biosensors integration in BBB-oC. In this direction, we name potential biomarkers to monitor the evolution of NDDs related to the BBB and/or drug cytotoxicity using biosensor technology in BBB-oC.

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Miniaturizable Ion-Selective Arrays Based on Highly Stable Polymer Membranes for Biomedical Applications

Cited by 29 publications

References 21 publications

Wearable sweat sensors

Wearable sweat sensors

Disposable Multi-Walled Carbon Nanotubes-Based Plasticizer-Free Solid-Contact Pb2+-Selective Electrodes with a Sub-PPB Detection Limit †

Biosensors Integration in Blood–Brain Barrier-on-a-Chip: Emerging Platform for Monitoring Neurodegenerative Diseases

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