Miniaturization of environmental chemical assays in flowing systems: The lab-on-a-valve approach vis-à-vis lab-on-a-chip microfluidic devices

Miró, Manuel; Hansen, Elo Harald

doi:10.1016/j.aca.2007.02.035

Cited by 86 publications

(40 citation statements)

References 80 publications

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“…Readers are referred to a recent comprehensive review by Miró and Hansen [16] for a critical discussion of pros and cons of LOV as compared to LOC Microsystems for automated SPE.…”

Section: Lab-on-valvementioning

confidence: 99%

Recent developments in automatic solid-phase extraction with renewable surfaces exploiting flow-based approaches

Miró

Hartwell

Jakmunee

et al. 2008

TrAC Trends in Analytical Chemistry

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. (2008). Recent developments in automatic solid-phase extraction with renewable surfaces exploiting flow-based approaches. TRAC -Trends in Analytical Chemistry, 27(9), 749-761. DOI: 10.1016749-761. DOI: 10. /j.trac.2008 TrAC MS:08-00052-REVISED Abstract: Solid-phase extraction (SPE) has been consolidated as the most versatile sample processing method for removal of interfering species and/or analyte enrichment. Although significant advances have been conducted over the past two decades for automation of the entire analytical protocol involving SPE via flow injection approaches, on-line SPE assays performed in a permanent mode lack sufficient reliability as a consequence of the progressive tighter packing of the bead reactor, contamination of the solid surfaces and potential leakage of functional moieties. This article overviews the current state-of-the-art of an appealing tool for overcoming the above shortcomings, the so-called bead injection (BI) analysis, based on automated renewal of the sorbent material per assay exploiting the various generations of flow injection analysis. It addresses novel instrumental developments for implementation of BI and a number of alternatives for on-line chemical derivatization reactions and pinpoints the most common instrumental detection techniques utilised. Relevant environmental and bioanalytical applications reported within the past few years are presented and discussed in detail.

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“…Readers are referred to a recent comprehensive review by Miró and Hansen [16] for a critical discussion of pros and cons of LOV as compared to LOC Microsystems for automated SPE.…”

Section: Lab-on-valvementioning

confidence: 99%

Recent developments in automatic solid-phase extraction with renewable surfaces exploiting flow-based approaches

Miró

Hartwell

Jakmunee

et al. 2008

TrAC Trends in Analytical Chemistry

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“…In addition, the low flow resistance of short and wide flow conduits allows precise flow manipulation, and the use of ultra fast bursts of flow that can wash out the channels rapidly and easily remove stray air bubbles or clogging particles. Readers are referred to a recently published comprehensive review article for a detailed and critical comparison of LOV and LOC micromachined units (84).…”

Section: X6 Microfluidic Devices: Lab-on-valvementioning

confidence: 99%

Flow Injection Analysis in Industrial Biotechnology

Hansen

Miró

2009

Encyclopedia of Industrial Biotechnology

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Flow injection analysis (FIA) is an analytical chemical continuous flow (CF) method which, in contrast to traditional CF procedures, does not rely on complete physical mixing (homogenization) of the sample and the reagent(s) or on attaining chemical equilibria of the chemical reactions involved. Exploiting controllable dispersion of the injected sample within the reagent‐containing carrier stream and strictly reproducible timing of all events taking place, it is based on measuring transient signals, which not only implies very high sampling rates but also, and most importantly, permits implementation of a number of novel methodologies that are not feasible when performed under batch conditions or by conventional CF procedures. Demonstrated for selected bioanalytical and technological applications encompassing cellular and enzymatic assays as well as monitoring of culture media, the principles and operational characteristics of FIA are first outlined, and then its downscaled/miniaturized sequels, that is, sequential injection analysis (SIA) and lab‐on‐valve (LOV), are detailed. Thus, in SIA the sample and reagents are, via the use of a multi‐position valve and an attached syringe pump operated under full programmable control, aspirated sequentially and then propelled forward allowing the sample and reagent(s) to be intermixed and, if called for, subjected to appropriate treatments before analyte detection. This infers that, merely minute sample/reagent volumes are consumed, hence leading to generation of small amounts of waste. In LOV this downscaling is taken further by using a small monolithic structure within which all sample manipulations and ultimate analyte detection under programmable control can be effected. Even bead materials with different surface groups/characteristics, including live cells, can be handled and utilized as demonstrated. Because the syringe pump in SIA and LOV can be used for accurately aspirating, propelling or even stopping the flow, these modi operandi allow fully to exploit the interplay between the kinetics and the thermodynamics of the chemical reactions involved, so that there are no restrictions whatsoever as to the chemistries that can be implemented, even if they entail multistep reactions. Representative bioanalytical examples of this interplay are presented.

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“…7 It has now been recognized as a universal tool for the accommodation of a wide variety of micro-scale analytical processes. 8 Later, Cerda proposed a chip-on-valve for the miniaturization of multisyringe flow-injection analysis. 9,10 The analyzer included a special panel equipped by four syringes for one-off moving of the sample and reagent solutions.…”

Section: Introductionmentioning

confidence: 99%