Miniaturization

Weston, Andrea

doi:10.1016/b978-012136640-7/50008-8

Cited by 5 publications

(11 citation statements)

References 58 publications

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“…O universo de aplicações da eletroforese capilar tem se mostrado em crescimento exponencial, pois várias classes de compostos são passíveis de serem analisados. Podem ser estudados desde simples íons inorgânicos e orgânicos 9,10 , até ácidos nuclêicos 11 , proteínas 12 e células 13 .…”

Section: Introductionunclassified

Implementação de um sistema de eletroforese capilar com detecção de fluorescência induzida por laser

Santos¹,

Tavares²,

Rubim³

2000

Quím. Nova

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CP 04478-70919-970-Brasília-DF Recebido em 9/2/99; aceito em 12/4/00 DEVELOPMENT OF A LASER INDUCED FLUORESCENCE DETECTION SCHEME FOR CAPILLARY ELECTROPHORESIS. A capillary electrophoresis system using laser induced fluorescence detection is described. A Raman system equipped with a microscope has been used to focus the laser beam on the capillary giving a lateral resolution of 1.5 mm. The fluorescence signal of the analyte (ZnPcTS-tetrasulfonated zinc-phthalocyanine) was collected by the microscope objectives and analysed by a monochromator with confocal characteristics equipped with a CCD detector. Electropherograms obtained with this system were compared to those obtained on a commercial instrument, showing that the described system presents a lower detection limit and better resolution.

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Section: Introductionunclassified

Implementação de um sistema de eletroforese capilar com detecção de fluorescência induzida por laser

Santos¹,

Tavares²,

Rubim³

2000

Quím. Nova

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“…Octyl (C 8 ) columns have wide applicability. This phase is less retentive than the C 18 phases, but is still quite useful for pharmaceuticals. Example: include (Zorbax SB-C 8 , Luna C 8 and YMC-Pack-MOS).…”

Section: Column Selectionmentioning

confidence: 99%

“…Octadecyl (C 18 , ODS) columns are the most widely used and tend to be the most retentive for non-polar analytes. Examples include Zorbax SB-C 18 , YMC-Pack ODS and Luna C 18 . Xterra RP-C 18 and Zorbax Extend-C 18 columns have been formulated to tolerate high pH systems (pH >7, normally up to pH 11).…”

Section: Column Selectionmentioning

confidence: 99%

“…Examples include Zorbax SB-C 18 , YMC-Pack ODS and Luna C 18 . Xterra RP-C 18 and Zorbax Extend-C 18 columns have been formulated to tolerate high pH systems (pH >7, normally up to pH 11). Varying the pH can affect selectivity and resolution of polar analytes, especially for ionizable compounds.…”

Section: Column Selectionmentioning

confidence: 99%

“…Examples include Zorbax SB-CN, Luna-CN, and YMC-Pack CN. The type of column chosen for a particular separation depends on the compound and the aim of analysis [16][17][18][19] .…”

Section: Column Selectionmentioning

confidence: 99%

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HPLC Method Development and Validation: A Review

Sabir¹,

Mehrabani²,

Bhasin³

2016

Int. Res. J. Pharm.

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High performance liquid chromatography (HPLC) is an essential analytical tool in assessing drug product. HPLC methods should be able to separate, detect, and quantify the various drugs and drug related degradants that can form on storage or manufacturing, detect and quantify any drugs and drug-related impurities that may be introduced during synthesis. Validation is the process of establishing the performance characteristics and limitations of a method and identification of the influences which may change these characteristics and to what extent. This article discusses the strategies and the issues pertinent to designing HPLC method development and validation.

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