Miniaturized biocompatible cardiopulmonary bypass for the Fontan procedure

Miyaji, Kagami; Miyamoto, Takashi; Inoue, Nobuyuki; Tomoyasu, Takahiro; Kohira, Satoshi; Sato, Hajime; Ohara, Kuniyoshi

doi:10.1007/s00595-009-4178-3

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…Ten months after surgery, computational fluid dynamics (CFD) analysis, a method described in previous studies and Supplemental Appendix , 2 , 3 was performed to evaluate detailed hemodynamics ( Figure 1 , Videos 1 and 2 ). The streamline of blood flow revealed a turbulent flow in the main pulmonary artery (MPA), left pulmonary artery (LPA), and proximal RPA, whereas a smooth laminar flow was observed in the SVC and distal RPA ( Figure 1A , Video 1 ).…”

Section: Clinical Vignettementioning

confidence: 99%

Computed Fluid Dynamics Analysis for SVC-to-RPA Anastomosis With Antegrade Pulmonary Flow

Sumitomo,

Kodo,

Oyanagi

et al. 2024

JACC: Case Reports

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Section: Clinical Vignettementioning

confidence: 99%

Computed Fluid Dynamics Analysis for SVC-to-RPA Anastomosis With Antegrade Pulmonary Flow

Sumitomo,

Kodo,

Oyanagi

et al. 2024

JACC: Case Reports

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“…Miyaji et al [ 86 ] successfully used mini-CPB in neonates weighing more than 4 kg. A more recent study by the same group demonstrated reduced inflammatory response with the use of mini-CPB in patients undergoing the Fontan procedure [ 87 ]. To our knowledge, there are no studies investigating differences between oxidative stress with conventional CPB and mini-CPB in paediatric heart surgery.…”

Section: Modulation Of Oxidative Stress In Paediatric Heart Surgermentioning

confidence: 99%

Oxidative Stress after Surgery on the Immature Heart

Fudulu

Angelini

2016

Oxidative Medicine and Cellular Longevity

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Paediatric heart surgery is associated with increased inflammation and the production of reactive oxygen species. Use of the extracorporeal cardiopulmonary bypass during correction of congenital heart defects generates reactive oxygen species by various mechanisms: haemolysis, neutrophil activation, ischaemia reperfusion injury, reoxygenation injury, or depletion of the endogenous antioxidants. The immature myocardium is more vulnerable to reactive oxygen species because of developmental differences compared to the adult heart but also because of associated congenital heart diseases that can deplete its antioxidant reserve. Oxidative stress can be manipulated by various interventions: exogenous antioxidants, use of steroids, cardioplegia, blood prime strategies, or miniaturisation of the cardiopulmonary bypass circuit. However, it is unclear if modulation of the redox pathways can alter clinical outcomes. Further studies powered to look at clinical outcomes are needed to define the role of oxidative stress in paediatric patients.

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Identification of Inflammatory Mediators and Their Modulation by Strategies for the Management of the Systemic Inflammatory Response During Cardiac Surgery

Hall

2013

Journal of Cardiothoracic and Vascular Anesthesia

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Miniaturized biocompatible cardiopulmonary bypass for the Fontan procedure

Abstract: The miniaturized biocompatible CPB system reduced perioperative inflammatory responses.

Cited by 3 publications

References 14 publications

Computed Fluid Dynamics Analysis for SVC-to-RPA Anastomosis With Antegrade Pulmonary Flow

Computed Fluid Dynamics Analysis for SVC-to-RPA Anastomosis With Antegrade Pulmonary Flow

Oxidative Stress after Surgery on the Immature Heart

Identification of Inflammatory Mediators and Their Modulation by Strategies for the Management of the Systemic Inflammatory Response During Cardiac Surgery

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