Miniaturized Fluorometer Based on Total Internal Reflector and Condensing Mirror

Jang, Daeho; Yoo, Jisu

doi:10.3807/josk.2013.17.1.081

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…One promising methodology using TIR phenomena was presented in Jang and Yoo (2013), where a fluorometer integrating a total internal reflector was introduced, a condensing mirror and the detection chamber (width 1.5 mm × depth 0.8 mm × length 5 mm) within a single 1.2 mm thick polycarbonate substrate. The total internal reflector enabled orthogonal detection, and the condensing mirror increased the selectivity of the fluorescence emission.…”

Section: Optics Layer-integrated Designsmentioning

confidence: 99%

Miniaturization of fluorescence sensing in optofluidic devices

Măriuța

Colin

Barrot-Lattes

et al. 2020

Microfluid Nanofluid

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Successful development of a micro-total-analysis system (µTAS, lab-on-a-chip) is strictly related to the degree of miniaturization, integration, autonomy, sensitivity, selectivity, and repeatability of its detector. Fluorescence sensing is an optical detection method used for a large variety of biological and chemical assays, and its full integration within lab-on-a-chip devices remains a challenge. Important achievements were reported during the last few years, including improvements of previously reported methodologies, as well as new integration strategies. However, a universal paradigm remains elusive. This review considers achievements in the field of fluorescence sensing miniaturization, starting from off-chip approaches, representing miniaturized versions of their lab counter-parts, continuing gradually with strategies that aim to fully integrate fluorescence detection on-chip, and reporting the results around integration strategies based on optical-fiber-based designs, optical layer integrated designs, CMOS-based fluorescence sensing, and organic electronics. Further successful development in this field would enable the implementation of sensing networks in specific environments that, when coupled to Internet-of-Things (IoT) and artificial intelligence (AI), could provide real-time data collection and, therefore, revolutionize fields like health, environmental, and industrial sensing.

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Section: Optics Layer-integrated Designsmentioning

confidence: 99%

Miniaturization of fluorescence sensing in optofluidic devices

Măriuța

Colin

Barrot-Lattes

et al. 2020

Microfluid Nanofluid

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“…In terms of minimizing the requirement of the high performance thin-film filter, utilizing a very short excitation pulse and applying some optical waveguide structures as depicted in [ 78 ] to separate the excitation and emission are also useful methods.…”

Section: Perspectivementioning

confidence: 99%

Recent Advances in Fluorescence Lifetime Analytical Microsystems: Contact Optics and CMOS Time-Resolved Electronics

Wei

Yan

2017

Sensors

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Fluorescence spectroscopy has become a prominent research tool with wide applications in medical diagnostics and bio-imaging. However, the realization of combined high-performance, portable, and low-cost spectroscopic sensors still remains a challenge, which has limited the technique to the laboratories. A fluorescence lifetime measurement seeks to obtain the characteristic lifetime from the fluorescence decay profile. Time-correlated single photon counting (TCSPC) and time-gated techniques are two key variations of time-resolved measurements. However, commercial time-resolved analysis systems typically contain complex optics and discrete electronic components, which lead to bulkiness and a high cost. These two limitations can be significantly mitigated using contact sensing and complementary metal-oxide-semiconductor (CMOS) implementation. Contact sensing simplifies the optics, whereas CMOS technology enables on-chip, arrayed detection and signal processing, significantly reducing size and power consumption. This paper examines recent advances in contact sensing and CMOS time-resolved circuits for the realization of fully integrated fluorescence lifetime measurement microsystems. The high level of performance from recently reported prototypes suggests that the CMOS-based contact sensing microsystems are emerging as sound technologies for application-specific, low-cost, and portable time-resolved diagnostic devices.

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Filter-less optical detection of multiple fluorophores

Azhar

Mohan

et al. 2019

Applied Industrial Optics 2019

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Miniaturized Fluorometer Based on Total Internal Reflector and Condensing Mirror

Cited by 3 publications

References 13 publications

Miniaturization of fluorescence sensing in optofluidic devices

Miniaturization of fluorescence sensing in optofluidic devices

Recent Advances in Fluorescence Lifetime Analytical Microsystems: Contact Optics and CMOS Time-Resolved Electronics

Filter-less optical detection of multiple fluorophores

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