Miniemulsification by catastrophic phase inversion

Campbell, Sorcha; Larson, Todd; Smeets, Niels M. B.; El-Jaby, Ula; McKenna, Timothy F. L.

doi:10.1016/j.cej.2011.12.092

Cited by 11 publications

(4 citation statements)

References 33 publications

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“…Mini‐emulsions were prepared from a combination of catastrophic phase inversion (PIC) and high‐shear technique by a rotor/stator mixer. This combination method proves to be almost four times more energy efficient than possible with a direct high‐shear technique .…”

Section: Comparative or Combination Study Of Low‐/high‐energy Methodsmentioning

confidence: 97%

“…For the high‐energy methods, a considerable investment (i.e. equipment and high‐energy consumption) is necessary for industrial‐scale production compared to the low‐energy method (where the concept is based on the chemical energy stored in the system). However, the high‐energy method has an advantage as the process time can be considered lower than the low‐energy method in a large‐scale production .…”

Section: High‐energy and Low‐energy Methods Comparison: Differences Amentioning

confidence: 99%

“…Limited to small batches [13,16,21] High-pressure homogenization Shear, collision and cavitation mechanism More flexible on surfactant and internal structure selection than low-energy process; low process time [13,16,21] equipment and high-energy consumption) is necessary for industrial-scale production [46] compared to the low-energy method (where the concept is based on the chemical energy stored in the system). However, the high-energy method has an advantage as the process time can be considered lower than the low-energy method in a large-scale production [42].…”

Section: Nanoemulsion Process Operation Principles Advantages Disadvamentioning

confidence: 99%

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Nanoemulsion: process selection and application in cosmetics – a review

Yukuyama

Ghisleni

Pinto

et al. 2015

Intern J of Cosmetic Sci

269

171

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SynopsisIn recent decades, considerable and continuous growth in consumer demand in the cosmetics field has spurred the development of sophisticated formulations, aiming at high performance, attractive appearance, sensorial benefit and safety. Yet despite increasing demand from consumers, the formulator faces certain restrictions regarding the optimum equilibrium between the active compound concentration and the formulation base taking into account the nature of the skin structure, mainly concerning to the ideal penetration of the active compound, due to the natural skin barrier. Emulsion is a mixture of two immiscible phases, and the interest in nanoscale emulsion has been growing considerably in recent decades due to its specific attributes such as high stability, attractive appearance and drug delivery properties; therefore, performance is expected to improve using a lipid-based nanocarrier. Nanoemulsions are generated by different approaches: the so-called high-energy and low-energy methods. The global overview of these mechanisms and different alternatives for each method are presented in this paper, along with their benefits and drawbacks. As a cosmetics formulation is reflected in product delivery to consumers, nanoemulsion development with prospects for large-scale production is one of the key attributes in the method selection process. Thus, the aim of this review was to highlight the main high-and low-energy methods applicable in cosmetics and dermatological product development, their specificities, recent research on these methods in the cosmetics and consideration for the process selection optimization. The specific process with regard to inorganic nanoparticles, polymer nanoparticles and nanocapsule formulation is not considered in this paper.R esum e Au cours des derni eres d ecennies, la croissance consid erable et continue de la demande des consommateurs dans le domaine des cosm etiques a stimul e le d eveloppement de formulations sophistiqu ees, visant a haute performance, de belle apparence, de l'avantage sensoriel et de la s ecurit e. Pourtant, malgr e la demande croissante des consommateurs, le formulateur est confront e a certaines restrictions concernant l' equilibre optimal entre la concentration en substance active et la base de la formulation, en tenant compte de la nature de la structure de la peau, concernant principalement a la p en etration id eale de la substance active, en raison de la nature barri ere de la peau. Une emulsion est un m elange de deux phases non miscibles, et l'int erêt en emulsion a l' echelle nanom etrique a augment e consid erablement au cours des derni eres d ecennies en raison de ses attributs sp ecifiques tels que grande stabilit e, les propri et es d'apparence et de vectorisation d'actifs attrayantes; par cons equent, on peut attendre une am elioration des performances par l'utilisation d'un nanocarrier a base de lipides. Les nano emulsions sont g en er ees par diff erentes approches: les m ethodes dites de haute energie et de faible energie. La vue d'ensembl...

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Section: Comparative or Combination Study Of Low‐/high‐energy Methodsmentioning

confidence: 97%

Section: High‐energy and Low‐energy Methods Comparison: Differences Amentioning

confidence: 99%

Section: Nanoemulsion Process Operation Principles Advantages Disadvamentioning

confidence: 99%

See 1 more Smart Citation

Nanoemulsion: process selection and application in cosmetics – a review

Yukuyama

Ghisleni

Pinto

et al. 2015

Intern J of Cosmetic Sci

269

171

View full text Add to dashboard Cite

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“…Of particular relevance, using AMF-based heating to trigger a glass transition is an established method to fabricate shape memory materials by releasing stresses trapped in the glassy state upon processing by heating above the T g value. − Instead, in this application, the combination of SPIONs with nanoparticles having a T g above normal physiological temperature but below any temperature that causes significant tissue damage over short–moderate term exposure (>45 °C) enables the triggering of a glass transition upon AMF heating; subsequent removal of the AMF allows the material to cool back down to ambient temperature and restore the glassy, low-diffusion state of the drug-loaded nanoparticles (Figure ). The p(MMA- co -BMA) nanoparticles were fabricated by miniemulsion polymerization, in which each monomer droplet acts as its own individual reactor, − allowing for the direct loading of a poorly water-soluble drug (here, using rhodamine B as a model) into the particles directly during assembly. By mixing tunable amounts of both SPIONs and T g nanoparticles into the pregel solution, well-defined and direct control over local heating, drug loading, and release kinetics can be achieved using all noncytotoxic components, ,− suggesting the potential translatability of this approach to the clinic.…”

Section: Introductionmentioning

confidence: 99%

Injectable On-Demand Pulsatile Drug Delivery Hydrogels Using Alternating Magnetic Field-Triggered Polymer Glass Transitions

Campbell,

Preciado Rivera,

Said

et al. 2023

ACS Appl. Mater. Interfaces

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Remote-controlled pulsatile or staged release has significant potential in a wide range of therapeutic treatments. However, most current approaches are hindered by the low resolution between the on-and off-states of drug release and the need for surgical implantation of larger controlled-release devices. Herein, we describe a method that addresses these limitations by combining injectable hydrogels, superparamagnetic iron oxide nanoparticles (SPIONs) that heat when exposed to an alternating magnetic field (AMF), and polymeric nanoparticles with a glass transition temperature (T g ) just above physiological temperature. Miniemulsion polymerization was used to fabricate poly(methyl methacrylate-co-butyl methacrylate) (p(MMA-co-BMA)) nanoparticles loaded with a model hydrophobic drug and tuned to have a T g value just above physiological temperature (∼43 °C). Co-encapsulation of these drug-loaded nanoparticles with SPIONs inside a carbohydrate-based injectable hydrogel matrix (formed by rapid hydrazone cross-linking chemistry) enables injection and immobilization of the nanoparticles at the target site. Temperature cycling facilitated a 2.5:1 to 6:1 on/off rhodamine release ratio when the nanocomposites were switched between 37 and 45 °C; release was similarly enhanced by exposing the nanocomposite hydrogel to an AMF to drive heating, with enhanced release upon pulsing observed even 1 week after injection. Coupled with the apparent cytocompatibility of all of the nanocomposite components, these injectable nanocomposite hydrogels are promising as minimally invasive but remotely actuated release delivery vehicles capable of complex release kinetics with high on−off resolution.

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