Minimal change disease and acute interstitial nephritis following SARS-CoV-2 BNT162b2 vaccination

Jongvilaikasem, Pondtip; Rianthavorn, Pornpimol

doi:10.1007/s00467-022-05470-z

Cited by 16 publications

(9 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After that, additional 85 articles were identified from other resources. Finally, 464 studies were included for qualitative and quantitative analysis [ 11 ], [ [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] , [72] , [73] , [74] , [75] , [76] , [77] , [78] , [79] , [80] , ...…”

Section: Resultsmentioning

confidence: 99%

Autoimmune and autoinflammatory conditions after COVID-19 vaccination. New case reports and updated literature review

Rodríguez

Rojas

Beltrán

et al. 2022

Journal of Autoimmunity

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Autoimmune and autoinflammatory conditions after COVID-19 vaccination. New case reports and updated literature review

Rodríguez

Rojas

Beltrán

et al. 2022

Journal of Autoimmunity

View full text Add to dashboard Cite

“…One patient presented with an overlap of MCD and TIN. All reported cases had good response to steroid treatment [ 24 , 25 , 26 , 27 , 28 ].…”

Section: Resultsmentioning

confidence: 99%

Intrinsic Kidney Pathology in Children and Adolescents Following COVID-19 Vaccination: A Systematic Review

Shenoy

Kalra

et al. 2022

Children

View full text Add to dashboard Cite

Global COVID-19 vaccination programs for children and adolescents have been developed with international clinical trial data confirming COVID-19 mRNA vaccine safety and efficacy for the pediatric population. The impact of COVID-19 vaccination in the kidneys is thought to be explained by a complex immune-mediated relationship between the two, although the pathophysiological mechanisms of how COVID-19 vaccination potentially induces kidney pathology are not presently well known. Whilst intrinsic kidney pathologies following COVID-19 vaccination have been reported in adults, such cases are only being recently reported with greater frequency in children and adolescents. Conforming to the PRISMA checklist, we conducted a systematic review of the current literature to provide an overview on the range of intrinsic kidney pathologies that have been reported following COVID-19 vaccination in children and adolescents. All English language research articles published on or before 30 June 2022 reporting new-onset or relapsed intrinsic kidney pathology in children or adolescents (≤18 years) following COVID-19 vaccination were selected for qualitative analysis. Out of 18 cases from the 13 published articles selected, there were 10 cases of IgA nephropathy (1 case of rapidly progressive glomerulonephritis requiring acute hemodialysis), 5 cases of minimal change disease (MCD), 1 case of concurrent MCD/tubulointerstitial nephritis (TIN) and 2 cases of TIN. There is no indication currently to avoid vaccination, unless specific circumstances exist, as the benefits of COVID-19 vaccination far outweigh its risks. Concluding the findings from our systematic review based on preliminary evidence, potential adverse effects to the kidney from COVID-19 vaccination affects a small number of children and adolescents among the many who have been vaccinated. There remains good reason at present to support vaccination of children and adolescents with a greater morbidity status, such as those living with preexisting chronic kidney disease. Close observation of all children and adolescents receiving COVID-19 vaccination is recommended, particularly in those with preceding intrinsic kidney pathology to identify risks of relapsed disease.

show abstract

“…It was suggested that the T-cell-mediated immune response to the SARS-CoV-2 vaccine was a trigger of the podocytopathy. Unlike the two cases described above, only partial remission was achieved after 5 weeks of treatment with corticosteroids [ 4 ].…”

Section: Lessons For the Clinical Nephrologistmentioning

confidence: 99%

“…However, causal confirmation of the relationship with vaccination remains challenging and is not always beyond doubt. Acute interstitial nephritis (AIN) has also recently been linked to SARS-CoV-2 vaccination [1][2][3][4]. Of note, in the largest series of 5 cases published to date, two patients with severely elevated serum creatinine levels of 268 and 355 µmol/l had evidence of concurrent focal segmental glomerulosclerosis on biopsy just 3 days and "a few days", respectively, after vaccination, suggesting that renal disease was likely pre-existing.…”

Section: Lessons For the Clinical Nephrologistmentioning

confidence: 99%

Biopsy-proven acute interstitial nephritis after SARS-CoV-2 mRNA vaccination—adverse vaccine side effect or unrelated complication from self-medication? Lessons for the clinical nephrologist

et al. 2022

View full text Add to dashboard Cite

Minimal change disease and acute interstitial nephritis following SARS-CoV-2 BNT162b2 vaccination

Cited by 16 publications

References 3 publications

Autoimmune and autoinflammatory conditions after COVID-19 vaccination. New case reports and updated literature review

Autoimmune and autoinflammatory conditions after COVID-19 vaccination. New case reports and updated literature review

Intrinsic Kidney Pathology in Children and Adolescents Following COVID-19 Vaccination: A Systematic Review

Biopsy-proven acute interstitial nephritis after SARS-CoV-2 mRNA vaccination—adverse vaccine side effect or unrelated complication from self-medication? Lessons for the clinical nephrologist

Contact Info

Product

Resources

About