Minimal-Change Glomerulopathy and Glomerular Visceral Epithelial Hyperplasia Associated with Alpha-lnterferon Therapy for Cutaneous T-Cell Lymphoma

Traynor, Ann E.; Kuzel, Timothy M.; Samuelson, Ellen; Kanwar, Yashpal S.

doi:10.1159/000187894

Cited by 48 publications

(23 citation statements)

References 10 publications

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“…IFN-α therapy has been implicated in various renal diseases such as renal thrombotic microangiopathy (in patients with chronic leukemia) [12], interstitial nephritis [13], and glomerular diseases including podocytopathies (focal segmental glomerulosclerosis and minimal change disease) or immune complex glomerulonephritis (membranous nephropathy, membrano-proliferative glomerulonephritis, IgA nephropathy), as shown in several case reports published over the last 20 years [14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30]. In addition, case series have been published [31].…”

Section: Discussionmentioning

confidence: 99%

“…Additional papers provided evidence of exacerbation of pre-existing glomerular disease during IFN [32,33]. The usual presentation of glomerular disease associated with IFN is isolated proteinuria, and nephrotic syndrome [14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31]. In a minority of patients, nephritic syndrome with renal failure has been recorded.…”

Section: Discussionmentioning

confidence: 99%

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Acute Tubular Necrosis Following Interferon-Based Therapy for Hepatitis C: Case Study with Literature Review

Fabrizi

Aghemo

Fogazzi

et al. 2013

Kidney Blood Press Res

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Background/Aims: Interferon treatment of malignant or viral diseases can be accompanied by various side-effects including nephro-toxicity. Methods: We report on a 68-year-old Caucasian male who received dual therapy with pegylated interferon 2a plus ribavirin for chronic hepatitis C. Results: After three months of antiviral therapy, the patient developed acute kidney failure (serum creatinine up to 6 mg/dL) with mild proteinuria (500 mg daily) and haematuria. Immediate immunosuppressive therapy with high-dose intravenous steroids did not improve kidney function. Kidney biopsy was consistent with acute tubular necrosis without glomerular abnormalities. He started long-term peritoneal dialysis (four regular exchanges) to provide both dialysis adequacy and ascites removal. Kidney function gradually improved over the following months (serum creatinine around 2 mg/dL) and peritoneal dialysis was continued with two exchanges daily. The temporal relationship between the administration of the drug and the occurrence of nephro-toxicity, and the absence of other obvious reasons for acute tubular necrosis support a causative role for pegylated interferon; benefit on kidney disease was noted after withdrawal of antiviral agents. An extensive review of the literature on acute tubular necrosis associated with interferon-based therapy, based on in vitro data and earlier case-reports, has been made. The proposed pathogenic mechanisms are reviewed. Conclusions: Our case emphasizes the importance of monitoring renal function during treatment of chronic hepatitis C with antiviral combination therapy as treatment may precipitate kidney damage at tubular level.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Acute Tubular Necrosis Following Interferon-Based Therapy for Hepatitis C: Case Study with Literature Review

Fabrizi

Aghemo

Fogazzi

et al. 2013

Kidney Blood Press Res

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“…There is a report that 15–20% of the patients given α-interferon develop proteinuria. Minimal-change nephrotic syndrome, focal segmental glomerulosclerosis, acute and chronic tubulointerstitial nephritis are reported to be induced by interferon, which was administered to treat malignancy or chronic hepatitis [1, 2, 3, 4, 5]. …”

Section: Introductionmentioning

confidence: 99%

Hemolytic Uremic Syndrome Associated with β-Interferon Therapy for Chronic Hepatitis C

Ubara¹,

Hara²,

Takedatu³

et al. 1998

Nephron

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“…IFN was discontinued in all patients, and eight also received steroids. A decline in proteinuria and improvement in renal function were documented in nine of 10 patients with available follow-up, although only one patient had a CR (39) and only three had a PR (40,44,46). Of note, all three reported patients with collapsing FSGS were receiving IFN-␣, including one (28) from our center, who also is included in this study (patient 2).…”

Section: Discussionmentioning

confidence: 93%

Treatment with IFN-α, -β, or -γ Is Associated with Collapsing Focal Segmental Glomerulosclerosis

Markowitz¹,

Nasr²,

Stokes³

et al. 2010

Clinical Journal of the American Society of Nephrology

204

180

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Background and objectives: Treatment with IFN is rarely associated with nephrotic syndrome and renal biopsy findings of minimal-change disease or FSGS.Design, setting, participants, & measurements: We report 11 cases of collapsing FSGS that developed during treatment with IFN and improved after discontinuation of therapy.Results: The cohort consists of seven women and four men with a mean age of 48.2 yr. Ten of the 11 patients were black. Six patients were receiving IFN-␣ for hepatitis C virus infection (n ‫؍‬ 5) or malignant melanoma (n ‫؍‬ 1), three were receiving IFN-␤ for multiple sclerosis, and two were treated with IFN-␥ for idiopathic pulmonary fibrosis. After a mean and median duration of therapy of 4.0 and 12.6 months, respectively, patients presented with acute renal failure (mean creatinine 3.5 mg/dl) and nephrotic-range proteinuria (mean 24-hour urine protein 9.7 g). Renal biopsy revealed collapsing FSGS with extensive foot process effacement and many endothelial tubuloreticular inclusions. Follow-up was available for 10 patients, all of whom discontinued IFN. At a mean of 23.6 months, nine of 10 patients had improvement in renal function, including one with complete remission and two with partial remission. Among the seven patients with available data, mean proteinuria declined from 9.9 to 3.0 g/d. Four of the seven patients were treated with immunosuppression, and there was no detectable benefit.Conclusions: Collapsing FSGS may occur after treatment with IFN-␣, -␤, or -␥ and is typically accompanied by the ultrastructural finding of endothelial tubuloreticular inclusions. Optimal therapy includes discontinuation of IFN.

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Minimal-Change Glomerulopathy and Glomerular Visceral Epithelial Hyperplasia Associated with Alpha-lnterferon Therapy for Cutaneous T-Cell Lymphoma

Cited by 48 publications

References 10 publications

Acute Tubular Necrosis Following Interferon-Based Therapy for Hepatitis C: Case Study with Literature Review

Acute Tubular Necrosis Following Interferon-Based Therapy for Hepatitis C: Case Study with Literature Review

Hemolytic Uremic Syndrome Associated with β-Interferon Therapy for Chronic Hepatitis C

Treatment with IFN-α, -β, or -γ Is Associated with Collapsing Focal Segmental Glomerulosclerosis

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