Minimal Clinically Important Differences (MCIDs) of the Thai Version of the Leicester Cough Questionnaire for Subacute and Chronic Cough

Pornsuriyasak, Prapaporn; Thungtitigul, Poungrat; Kawamatawong, Theerasuk; Birring, Surinder S.; Pongmesa, Tipaporn

doi:10.1016/j.vhri.2017.03.009

Cited by 10 publications

(8 citation statements)

References 31 publications

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“…This was because the sample size was calculated based on a larger change of total LCQ score (i.e., 3) from previous studies. 15,17) However, the threshold of changes in the total LCQ score could be achieved. A back-calculation of the power of our trial was 70%, but the lower boundary of the 95% CI of the treatment effect nearly reached 3 (i.e., 2.69), which was unfavourable towards the procaterol group.…”

Section: Discussionmentioning

confidence: 99%

“…15) The LCQ-T has been validated in a Thai population with chronic cough and the minimum clinically important difference has been determined. 16,17) Participants performed spirometry and methacholine challenge testing to determine whether they had baseline airway obstruction and to assess for airway hyperresponsiveness. We included those who had no airway obstruction, regardless of airway hyperresponsiveness, in the final analysis.…”

Section: Methodsmentioning

confidence: 99%

“…The sample size was calculated based on previous studies to have 80% power to detect the changes of the LCQ-T total score of 3, using a standard deviation (SD) of 4.0 and two-tailed α of 0.05. 15,17) The ratio of intervention/control was set at 1:1. The target sample size was 60 participants.…”

Section: Statistical Analysesmentioning

confidence: 99%

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Effects of Oral Procaterol for Postinfectious Cough in Adults: Single-Centre, Randomized Double-Blind, Placebo-Controlled Trial

et al. 2021

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Background: Persistent cough following an upper respiratory tract infection (URTI) is common in clinical practice. We investigated the effects of procaterol on cough-specific quality of life (QoL) and peripheral-airway function among adults suffering from postinfectious cough (PIC). Methods: This was a prospective, randomized, double-blinded placebo-controlled trial (NCT 02349919) conducted at a university hospital. Seventy-four non-asthmatic adults who had persistent post-URTI cough for ≥3 weeks were assessed by a physical examination, chest/paranasal sinus radiographs, spirometry, and impulse oscillometry (IOS) and were allocated to receive procaterol or placebo for 4 weeks. The Thai version of the Leicester Cough Questionnaire (LCQ-T), spirometry and IOS were assessed at baseline, 2 weeks, and 4 weeks. Results: Mean LCQ-T total scores for the procaterol group (10.8) and placebo group (10.9) at baseline were not significantly different (P=0.821). After adjustment for baseline Borg Cough Scale score and post-nasal drip, the mean between-group difference was not significant for LCQ-T total score (-1.26; 95% confidence interval [CI],-2.69 to 0.17), physical domain score (-0.35; 95% CI,-0.76 to 0.06), psychological domain score (-0.53; 95% CI,-1.06 to 0.01), or social domain score (-0.38; 95% CI,-0.92 to 0.16). Large improvements in LCQ-T total score were reported in both groups after 2 weeks (procaterol, 4.21±2.73; placebo, 5.34±3.2), and 4 weeks (procaterol, 5.94±3.68; placebo, 7.07±3.44). No differences between groups were found in the mean changes of spirometry or IOS parameters after 4 weeks. Conclusion: Our study shows that procaterol is not effective in the treatment of PIC, in terms of improvement of cough-specific QoL or peripheral-airway function.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Effects of Oral Procaterol for Postinfectious Cough in Adults: Single-Centre, Randomized Double-Blind, Placebo-Controlled Trial

et al. 2021

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“…Lower LCQ scores indicate more persistent cough. The MCID of the LCQ for subacute and chronic cough has been defined as 0.4, 0.4, 0.4 and 1.1 for the physical, psychological, social and total domains respectively (Pornsuriyasak, Thungtitigul, Kawamatawong, Birring, & Pongmesa, 2017).…”

Section: Outcome Measuresmentioning

confidence: 99%

Psychological distress at hospital admission is related to symptoms severity and health status in malignant pleural effusion patients

et al. 2019

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Objective The incidence and associated healthcare costs of malignant pleural effusion (MPE) are expected to rise, but there is limited evidence about which factors affect patients' prognosis. So, the aim of this study was to determine whether psychological distress at hospital admission is associated with symptom severity and health status in patients with MPE. Methods A longitudinal observational prospective cohort study was carried out in the Pulmonology Service of the Granada University Hospital Complex in Granada, Spain. Patients diagnosed with MPE were included and evaluated at hospital admission, at discharge and at one month after discharge. Outcome measures included symptom severity (i.e. dyspnoea, pain and cough) and health status (functionality and self‐perceived health status). Results Significant differences were found in symptoms and the health status, with worse results in the group with psychological distress at discharge. One month after discharge, MPE patients with psychological distress exhibited greater symptoms, including more cough and dyspnoea (p < .05). Moreover, these patients showed worse functionality (p < .05) and self‐perceived health status (p < .05). Conclusion Psychological distress is an important factor to take into account in patients with MPE. The presence of psychological distress appears to increase the symptoms and is associated with worse health status after hospitalisation.

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“…Since its rst introduction by Birring et al [6], the Leicester Cough Questionnaire (LCQ) has been regarded as a reliable tool for evaluating the cough in adults by a number of researchers [7][8][9] . Therefore, our goal was to prospectively analyze postoperative cough in patients undergoing thyroidectomy.…”

Section: Introductionmentioning

confidence: 99%

Incidence and risk factor for short term postoperative cough after thyroidectomy

Dai

Lou

2020

Preprint

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Background: The prevalence of and potential risk factors for postoperative cough after thyroidectomy remain unknown. The current study aimed to analyze postoperative cough in patients undergoing thyroidectomy using a prospective analysis.Methods: Adult patients undergoing primary thyroidectomy were prospectively enrolled. Data regarding age, sex, BMI, pathology and surgical procedure were collected and analyzed. All patients were asked to complete the Leicester Cough Questionnaire (LCQ) preoperatively and at 2 weeks and 4 weeks postoperatively.Results: There were 1264 patients enrolled in total. Eleven patients with vocal cord paralysis were excluded. In patients with benign disease, postoperative cough occurred in 61 patients, with an prevalence rate of 17. 0% compared to an prevalence rate of 33.1% in patients with malignant disease; the difference was significant. For benign patients, the factors of smoking and operation time were independently related to the occurrence of postoperative cough. For malignant patients, the factors of smoking, operation time, operation extent, and the number of positive nodes at level 6 were independently related to the occurrence of postoperative cough. There was no significant difference regarding the LCQ score in patients with benign or malignant disease at the preoperative and the postoperative 4-week time periods. Patients with malignant disease had a significantly lower LCQ score than patients with benign disease at the postoperative 2-week time point (p=0.004).Conclusions: Patients undergoing thyroid cancer surgery had a higher prevalence of postoperative cough and were also associated with a decreased cough-related quality of life. The factors of smoking and operation time were the most important predictors for postoperative cough after thyroidectomy.

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Minimal Clinically Important Differences (MCIDs) of the Thai Version of the Leicester Cough Questionnaire for Subacute and Chronic Cough

Abstract: The MCIDs of the LCQ-T for subacute and chronic cough are 1.1, 0.4, 0.4, and 0.4 for the total, physical, psychological, and social domains, respectively. These estimates should be useful in making meaningful interpretations of the changes in quality of life because of cough.

Cited by 10 publications

References 31 publications

Effects of Oral Procaterol for Postinfectious Cough in Adults: Single-Centre, Randomized Double-Blind, Placebo-Controlled Trial

Effects of Oral Procaterol for Postinfectious Cough in Adults: Single-Centre, Randomized Double-Blind, Placebo-Controlled Trial

Psychological distress at hospital admission is related to symptoms severity and health status in malignant pleural effusion patients

Incidence and risk factor for short term postoperative cough after thyroidectomy

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