Minimal effective dose of magnesium sulfate for attenuation of intubation response in hypertensive patients

Panda, Nidhi; Bharti, Neerja; Prasad, Seema

doi:10.1016/j.jclinane.2012.06.016

Cited by 47 publications

(44 citation statements)

References 15 publications

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“…An intraoperative infusion of magnesium sulphate significantly reduces the adrenergic response for surgical stress mediated by plasma epinephrine and norepinephrine concentrations [9,21]. Moreover, Mg attenuates the haemodynamic response on intubation in hypertensive patients [22]. Importantly, the majority of studied patients were treated for hypertension.…”

Section: Discussionmentioning

confidence: 99%

Plasma magnesium concentration in patients undergoing coronary artery bypass grafting

Kotlińska-Hasiec¹,

Makara‐Studzińska²,

Czajkowski³

et al. 2017

Ann Agric Environ Med.

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Plasma magnesium concentration in patients undergoing coronary artery bypass grafting Kotlinska-Hasiec E, Makara-Studzinska M, Czajkowski M, Rzecki Z, Olszewski K, Stadnik A, Pilat J, Rybojad B, Dabrowski W. Ann Agric Environ Med. 2017; 24(2): 181-184. doi: 10.5604/12321966.1232762 Abstract Introduction. Magnesium (Mg) plays a crucial role in cell physiology and its deficiency may cause many disorders which often require intensive treatment. The aim of this study was to analyse some factors affecting preoperative plasma Mg concentration in patients undergoing coronary artery bypass grafting (CABG). Materials and method. Adult patients scheduled for elective CABG with cardio-pulmonary bypass (CPB) under general anaesthesia were studied. Plasma Mg concentration was analysed before surgery in accordance with age, domicile, profession, tobacco smoking and preoperative Mg supplementation. Blood samples were obtained from the radial artery just before the administration of anaesthesia. Results. 150 patients were studied. Mean preoperative plasma Mg concentration was 0.93 ± 0.17 mmol/L; mean concentration in patients -1.02 ± 0.16; preoperative Mg supplementation was significantly higher than in patients without such supplementation. Moreover, intellectual workers supplemented Mg more frequently and had higher plasma Mg concentration than physical workers. Plasma Mg concentration decreases in elderly patients. Patients living in cities, on average, had the highest plasma Mg concentration. Smokers had significantly lower plasma Mg concentration than non-smokers. Conclusions. 1. Preoperative magnesium supplementation increases its plasma concentration. 2. Intellectual workers frequently supplement magnesium. 3. Smoking cigarettes decreases plasma magnesium concentration.

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Section: Discussionmentioning

confidence: 99%

Plasma magnesium concentration in patients undergoing coronary artery bypass grafting

Kotlińska-Hasiec¹,

Makara‐Studzińska²,

Czajkowski³

et al. 2017

Ann Agric Environ Med.

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“…6,7 Magnesium has long been used for its antihypertensive, anesthetic sparing effects and its property to enhance the effects of analgesics. 8,9 Magnesium, after administration through epidural route, decreased postoperative opioid jOrapain consumption. 6 Magnesium as adjuvant enhances the analgesic properties of established analgesics; it needs to be evaluated further when used as an adjuvant in perineural injection with local anesthetic in supraclavicular block.…”

Section: Introductionmentioning

confidence: 98%

Efficacy of Magnesium Sulfate as Adjuvant to Ropivacaine 0.4% for Supraclavicular Brachial Plexus Block in Patients undergoing Upper Limb Surgery: A Randomized Controlled Trial

Gupta

Mangal

Sharma

et al. 2017

Journal on Recent Advances in Pain

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Objectives: To prolong the duration of brachial plexus block, different adjuvants have been used. We evaluated the effect of adding magnesium sulfate to local anesthetic ropivacaine 0.4% for institution of supraclavicular brachia plexus block. Onset of sensory and motor block, duration of motor block, and rescue analgesia were observed. Materials and methods:Total 120 patients (20-50 years) scheduled for elective surgeries of upper limb under supraclavicular brachial plexus block were randomized into two groups. Group I received 24 mL 0.5% ropivacaine (120 mg) + 6.0 mL normal saline (NS) to make total volume of 30 mL. Group II received 24 mL 0.5% ropivacaine (120 mg) + 150 mg magnesium sulfate + 5.5 mL NS to make total volume of 30 mL. Results:Onset of sensory block in group I was 16.63 ± 2.79 min and in group II was 17.33 ± 2.25 min (statistically not significant, p > 0.05). Onset of motor block in group I was 18.63 ± 2.79 min and in group II was 19.76 ± 2.18 min (statistically significant, p < 0.05). The duration of motor block was significantly longer in group II; 322.00 ± 81.35 min than group I; 260.25 ± 66.79 min (p < 0.05). Similarly, time of rescue analgesia was significantly prolonged in group II; 491 ± 100.22 min than group I; 377.67 ± 73.31 min (p < 0.05). Conclusion:From our study, we concluded that the addition of 150 mg magnesium sulfate as adjuvant to 30 mL of 0.4% ropivacaine in comparison to 30 mL of 0.4% ropivacaine provides longer duration of analgesia. Although the onset of sensory block is not affected, onset of motor block is delayed. Motor block lasts for longer duration.

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“…Patients in Group H were older in age (p<0.001). Intubation response was seen in Group H but not in Group N. This is a known phenomenon, and various drugs have been advocated to reduce this effect (9,10).…”

Section: Discussionmentioning

confidence: 92%

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Turk J Anesth Reanim

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Minimal effective dose of magnesium sulfate for attenuation of intubation response in hypertensive patients

Cited by 47 publications

References 15 publications

Plasma magnesium concentration in patients undergoing coronary artery bypass grafting

Plasma magnesium concentration in patients undergoing coronary artery bypass grafting

Efficacy of Magnesium Sulfate as Adjuvant to Ropivacaine 0.4% for Supraclavicular Brachial Plexus Block in Patients undergoing Upper Limb Surgery: A Randomized Controlled Trial

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