Minimal-invasive Katheterverfahren in der Varizentherapie

Böhler, Kornelia

doi:10.1007/s00105-023-05113-w

Cited by 2 publications

(5 citation statements)

References 29 publications

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“…VV denotes vein tortuosity and expansion due to venous factors and blood-related issues ( Atkins et al, 2020 ; Bohler, 2023 ). Comparison of VV pathological tissues with normal surrounding tissues unveiled upregulation of tRF-36-F900BY4D-84KRIME and tRF-23-87R8WP9IY, alongside downregulation of tRF-40-86J8WPMN1E8Y7Z2R.…”

Section: Exploring Mapk-related Tsrnas In Disease: Identification Exp...mentioning

confidence: 99%

Unveiling the role of tRNA-derived small RNAs in MAPK signaling pathway: implications for cancer and beyond

Wang,

Huang,

Ying

et al. 2024

Front. Genet.

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tRNA-derived small RNAs (tsRNAs) are novel small non-coding RNAs originating from mature or precursor tRNAs (pre-tRNA), typically spanning 14 to 30 nt. The Mitogen-activated protein kinases (MAPK) pathway orchestrates cellular responses, influencing proliferation, differentiation, apoptosis, and transformation. tsRNAs influence the expression of the MAPK signaling pathway by targeting specific proteins within the pathway. Presently, four MAPK-linked tsRNAs have implications in gastric cancer (GC) and high-grade serous ovarian cancer (HGSOC). Notably, tRF-Glu-TTC-027 and tRF-Val-CAC-016 modulate MAPK-related protein expression, encompassing p38, Myc, ERK, CyclinD1, CyclinB, and c-Myc, hindering GC progression via MAPK pathway inhibition. Moreover, tRF-24-V29K9UV3IU and tRF-03357 remain unexplored in specific mechanisms. KEGG analysis posits varied tsRNAs in MAPK pathway modulation for diverse non-cancer maladies. Notably, high tRF-36-F900BY4D84KRIME and tRF-23-87R8WP9IY expression relates to varicose vein (VV) risk. Elevated tiRNA-Gly-GCC-001, tRF-Gly-GCC-012, tRF-Gly-GCC-013, and tRF-Gly-GCC-016 target spinal cord injury (SCI)-related brain-derived neurotrophic factor (BDNF), influencing MAPK expression. tRF-Gly-CCC-039 associates with diabetes foot sustained healing, while tRF-5014a inhibits autophagy-linked ATG5 in diabetic cardiomyopathy (DCM). Additionally, tsRNA-14783 influences keloid formation by regulating M2 macrophage polarization. Upregulation of tRF-Arg-ACG-007 and downregulation of tRF-Ser-GCT-008 are associated with diabetes. tsRNA-04002 alleviates Intervertebral disk degeneration (IDD) by targeting PRKCA. tsRNA-21109 alleviates Systemic lupus erythematosus (SLE) by inhibiting macrophage M1 polarization. The upregulated tiNA-Gly-GCC-002 and the downregulated tRF-Ala-AGC-010, tRF-Gln-CTG-005 and tRF-Leu-AAG-001 may be involved in the pathogenesis of Lupus nephritis (LN) by affecting the expression of MAPK pathway. Downregulation of tsRNA-1018, tsRNA-3045b, tsRNA-5021a and tsRNA-1020 affected the expression of MAPK pathway, thereby improving Acute lung injury (ALI). This review comprehensively dissects tsRNA roles in MAPK signaling across cancers and other diseases, illuminating a novel avenue for translational medical exploration.

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Section: Exploring Mapk-related Tsrnas In Disease: Identification Exp...mentioning

confidence: 99%

Unveiling the role of tRNA-derived small RNAs in MAPK signaling pathway: implications for cancer and beyond

Wang,

Huang,

Ying

et al. 2024

Front. Genet.

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“…Access to the greater saphenous vein is typically established just below the knee crease through a venous cut-down or direct puncture using a large-bore needle. Recent developments have expanded the range of options by enabling punching at the ankle, providing additional treatment possibilities [33].…”

Section: Endovenous Saphenous Vein Obliteration: a Minimally Invasive...mentioning

confidence: 99%

“…Transilluminated power phlebectomy is tailored to treat varicose veins in the thigh region. Distinguishing itself from stab phlebectomy, which entails multiple incisions and potential pain, hematomas, and scarring, transilluminated power phlebectomy aims to reduce complications by minimizing the number of incisions while effectively removing varicose veins [33]. During this procedure, a fiberoptic light channel equipped with a side port is inserted to provide illumination while infusing saline and local anesthetic.…”

Section: Transilluminated Power Phlebectomy: Minimizing Discomfort An...mentioning

confidence: 99%

“…The analysis aims to provide insights into the economic considerations of different treatment options for varicose veins, helping clinicians and policymakers make informed decisions based on cost-effectiveness and patient outcomes [39,40]. [23,25,27,33,34,36].…”

Section: Overall Analysis Of the Available Treatment Optionsmentioning

confidence: 99%

“…Laser ablation treatment is more suitable for minor to medium-sized veins and is less invasive, resulting in minimal scarring. However, patients should know the potential for post-treatment pigmentation [33,38,39].…”

Section: Laser Ablation Treatmentmentioning

confidence: 99%

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A Narrative Review of Advancements in Understanding and Treating Varicose Veins

Singh,

Gattani

2023

Cureus

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Chronic venous disease, with varicose veins as its archetypal manifestation, stands as a pervasive and intricate health quandary, encompassing a vast array of contributing factors. Age, genetics, obesity, pregnancy, and prolonged immobility weave a complex tapestry, underscoring the omnipresence of this ailment. Its societal and economic footprint is undeniably formidable, as diverse classifications underscore its multifaceted character. The intricate interplay of chronic venous disease with diabetes mellitus and neuropathy compounds the challenge, fostering soaring healthcare expenditures and a palpable erosion of quality of life, particularly among women harboring cardiometabolic risk factors. Despite research shedding light on heightened susceptibility within certain demographics, the enigmatic determinants orchestrating the transition from mild to severe chronic venous disease continue to elude us.Varicose veins, marked by the presence of dilated and tortuous subcutaneous vessels, precipitate both physical discomfort and cosmetic concerns, frequently necessitating meticulous clinical evaluation coupled with ultrasound studies to secure a precise diagnosis. Treatment strategies are strategically crafted to ameliorate distressing symptoms, enhance aesthetic concerns, and forestall potential complications. Nevertheless, the prognostication of chronic venous disease remains ensconced in a degree of ambiguity, hinting at the vast terrain yet to be charted in this medical domain. The quest to fathom the intricacies of this condition uncovers an ever-evolving panorama where conservative interventions play an indispensable role in managing mild cases, while interventional procedures like endovenous laser ablation and sclerotherapy step onto the stage for patients grappling with severe symptoms, thus treading the fine line between efficacy and invasiveness. Moreover, a meticulous economic analysis underscores the costeffectiveness of various therapeutic modalities, thereby bolstering the imperative of a patient-centered approach. As we navigate the labyrinthine complexities of chronic venous disease and varicose vein management, we are inexorably drawn to the pivotal role of customized treatment approaches, as well as the dynamic interplay between scientific progress, patient preferences, and therapeutic innovations in the relentless pursuit of optimized outcomes and an enhanced quality of life.

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Minimal-invasive Katheterverfahren in der Varizentherapie

Cited by 2 publications

References 29 publications

Unveiling the role of tRNA-derived small RNAs in MAPK signaling pathway: implications for cancer and beyond

Unveiling the role of tRNA-derived small RNAs in MAPK signaling pathway: implications for cancer and beyond

A Narrative Review of Advancements in Understanding and Treating Varicose Veins

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