We show that in SO(10) models, a Yukawa sector consisting of a real 10 H , a real 120 H and a complex 126 H of Higgs fields can provide a realistic fit to all fermion masses and mixings, including the neutrino sector. Although the group theory of SO(10) demands that the 10 H and 120 H be real, most constructions complexify these fields and impose symmetries exterior to SO(10) to achieve predictivity. The proposed new framework with real 10 H and real 120 H relies only on SO(10) gauge symmetry, and yet has a limited number of Yukawa parameters. Our analysis shows that while there are restrictions on the observables, a good fit to the entire fermion spectrum can be realized. Unification of gauge couplings is achieved with an intermediate scale Pati-Salam gauge symmetry. Proton decay branching ratios are calculable, with the leading decay modes being p → νπ + and p → e + π 0 .