Minimally invasive and continuous glucose monitoring sensor based on non-enzymatic porous platinum black-coated gold microneedles

Chinnadayyala, Somasekhar R.; Park, Jinsoo; Satti, Afraiz Tariq; Kim, Dae-Young; Cho, Sungbo

doi:10.1016/j.electacta.2020.137691

Cited by 50 publications

(28 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Figure 6 a shows the constant potential i vs. t response curves of the Au/Pt-black/Nf MNEA measured with wireless non-invasive CGM system fabricated in the present study with bare AuMN as the CE for the step-wise addition of glucose to study the analytical characteristics of the Pt-black-modified MNEAs. Our previous article reported the potential window of the glucose oxidation and suggested +0.12 V vs. Ag/AgCl as an optimized potential for chronoamperometry of AuMNs/Pt-black/Nf sensors [ 5 ]. Additionally, the potential window of the glucose oxidation (+0.0 V to +0.3 V) was shown in Figure S2 describing the cyclic voltammograms of the bare Au MNEA, Au/Pt-black and Au/Pt-black/Nf without or with the addition of 10 mM of glucose at a scan rate of 50 mV s −1 in 10 × PBS (pH = 7.4).…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, the continuous glucose measurement with high selectivity and sensitivity has gained considerable interest in various sectors such as the food industry, environmental monitoring and clinical diagnostics. Amid the different detection techniques available for the detection of varying glucose levels in the body, electrochemical detection methods have attracted significant attention due to their ability for mass production, their speed, their low cost, they are easy to commercialize, their high sensitivity, their use in point-of-care testing and the facile glucose electro-oxidation on the electrode surface [ 5 , 6 , 7 ]. Along with the glucose sensors, various wireless measurement methods are realized for continuous monitoring, but real-time validation, including an application-based smartphone display, has especially received publicity from the patients and clinical staff [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Sensitive Electrochemical Non-Enzymatic Detection of Glucose Based on Wireless Data Transmission

Kim

Chinnadayyala

et al. 2022

Sensors

Self Cite

View full text Add to dashboard Cite

Miniaturization and wireless continuous glucose monitoring are key factors for the successful management of diabetes. Electrochemical sensors are very versatile and can be easily miniaturized for wireless glucose monitoring. The authors report a microneedle-based enzyme-free electrochemical wireless sensor for painless and continuous glucose monitoring. The microneedles (MNs) fabricated consist of a 3 × 5 sharp and stainless-steel electrode array configuration. Each MN in the 3 × 5 array has 575 µm × 150 µm in height and width, respectively. A glucose-catalyzing layer, porous platinum black, was electrochemically deposited on the tips of the MNs by applying a fixed cathodic current of 2.5 mA cm−2 for a period of 200 s. For the non-interference glucose sensing, the platinum (Pt)-black-coated MN was carefully packaged into a biocompatible ionomer, nafion. The surface morphologies of the bare and modified MNs were studied using field-emission scanning electron microscopy (FESEM) and energy-dispersive X-ray analysis (EDX). The wireless glucose sensor displayed a broad linear range of glucose (1→30 mM), a good sensitivity and higher detection limit of 145.33 μA mM−1 cm−2 and 480 μM, respectively, with bare AuMN as a counter electrode. However, the wireless device showed an improved sensitivity and enhanced detection limit of 445.75, 165.83 μA mM−1 cm−2 and 268 μM, respectively, with the Pt-black-modified MN as a counter electrode. The sensor also exhibited a very good response time (2 s) and a limited interference effect on the detection of glucose in the presence of other electroactive oxidizing species, indicating a very fast and interference-free chronoamperometric response.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sensitive Electrochemical Non-Enzymatic Detection of Glucose Based on Wireless Data Transmission

Kim

Chinnadayyala

et al. 2022

Sensors

Self Cite

View full text Add to dashboard Cite

show abstract

“…The fourth-generation glucose sensors involving direct electro-oxidation of glucose to gluconic acid via non-enzymatic electron transfer employed nanoporous material for electrodes array: a highly porous platinum black (Pt-black). The system comprised a fabricated Au/Pt black-nafion as the working electrode and the Au/Ag/AgCl-nafion counter/reference electrode in a three-electrode setup used for the amperometric measurements [253]. A 150 µm stainless-steel substrate supported the needles with a length and width of 650µm and 110 µm respectively [248].…”

Section: Glucose Sensorsmentioning

confidence: 99%

E-Skin: The Dawn of a New Era of On-Body Monitoring Systems

et al. 2021

View full text Add to dashboard Cite

Real-time “on-body” monitoring of human physiological signals through wearable systems developed on flexible substrates (e-skin) is the next target in human health control and prevention, while an alternative to bulky diagnostic devices routinely used in clinics. The present work summarizes the recent trends in the development of e-skin systems. Firstly, we revised the material development for e-skin systems. Secondly, aspects related to fabrication techniques were presented. Next, the main applications of e-skin systems in monitoring, such as temperature, pulse, and other bio-electric signals related to health status, were analyzed. Finally, aspects regarding the power supply and signal processing were discussed. The special features of e-skin as identified contribute clearly to the developing potential as in situ diagnostic tool for further implementation in clinical practice at patient personal levels.

show abstract

“…Commercially available blood glucose devices differ among invasive, non-invasive, single-use, and continuous measurements. Invasive blood glucose meters are more accurate than non-invasive ones, and continuous measurements can show the change in blood glucose more clearly [ 13 , 14 ]. According to ISO15197, the error range of blood glucose meters can be accepted up to ±15%, which means there is still a lot of room for the development of a new blood glucose meter.…”

Section: Introductionmentioning

confidence: 99%

Continuous Glucose Monitoring System Based on Percutaneous Microneedle Array

et al. 2022

View full text Add to dashboard Cite

A continuous blood glucose monitoring system (CGMS) which include a microneedle-array blood glucose sensor, a circuit module, and a transmission module placed in a wearable device is developed in this research. When in use, the wearable device is attached to the human body with the microneedle array inserted under the skin for continuous blood glucose sensing, and the measured signals are transmitted wirelessly to a mobile phone or computer for analysis. The purpose of this study is to replace the conventionally used method of puncture for blood collection and test strips are used to measure the blood glucose signals. The microneedle sensor of this CGMS uses a 1 mm length needle in a 3 mm × 3 mm microneedle array for percutaneous minimally invasive blood glucose measurement. This size of microneedle does not cause bleeding damage to the body when used. The microneedle sensor is placed under the skin and their solutions are discussed. The blood glucose sensor measured the in vitro simulant fluid with a glucose concentration range of 50~400 mg/dL. In addition, a micro-transfer method is developed to accurately deposit the enzyme onto the tip of the microneedle, after which cyclic voltammetry (CV) is used to measure the glucose simulation solution to verify whether the difference in the amount of enzyme on each microneedle is less than 10%. Finally, various experiments and analyses are carried out to reduce the size of the device, test effective durability (approximately 7 days), and the feasibility of minimally invasive CGMS is evaluated by tests on two persons.

show abstract

Minimally invasive and continuous glucose monitoring sensor based on non-enzymatic porous platinum black-coated gold microneedles

Cited by 50 publications

References 47 publications

Sensitive Electrochemical Non-Enzymatic Detection of Glucose Based on Wireless Data Transmission

Sensitive Electrochemical Non-Enzymatic Detection of Glucose Based on Wireless Data Transmission

E-Skin: The Dawn of a New Era of On-Body Monitoring Systems

Continuous Glucose Monitoring System Based on Percutaneous Microneedle Array

Contact Info

Product

Resources

About