Minimally invasive colon resection is associated with a persistent increase in plasma PlGF levels following cancer resection

Abstract

PlGF levels are elevated for 3 weeks after MICR and PreOp plasma levels are higher in CRC patients than in BEN disease patients. The cause of the postoperative increase is unclear. The persistently higher blood levels of PlGF and VEGF after MICR may stimulate angiogenesis in residual tumor foci. Further studies regarding late blood protein alterations after surgery appear to be indicated.

Plasma chitinase 3-like 1 is persistently elevated during first month after minimally invasive colorectal cancer resection

“…In regards to the CRC Pre vs PostOp CHi3L1 comparisons, the results are reported as the median and 95%CIs and the Wilcoxon signed rank test was used to analyze the data. Correlation between PostOp CHi3L1 plasma levels and incision size and length of surgery was evaluated by the Spearman's rank correlation coefficient (rs) All data analysis was performed utilizing SPSS version 15 …”

“…We have demonstrated in several studies that elective surgery for CRC is associated with persistent plasma protein changes that render the blood proangiogenic for 2-3 wk as judged by in vitro invasion, migration and EC proliferation analysis [14][15][16][17][18] . This is in contradistinction to the vast majority of serum proteins that have been studied perioperatively whose levels are transiently elevated after major surgery (alterations resolving in < 1 wk such as IL-2, IL-6, CRP, etc).…”

“…It has been shown that colorectal resection is associated with continual elevations (2-5 wk) in the blood levels of a number of angiogenesis promoting proteins including vascular endothelial growth factor (VEGF), angiopoietin-2 (Ang-2), placental growth factor (PlGF), soluble vascular cell adhesion molecule-1 (sVCAM-1), monocyte chemotactic protein-1 (MCP-1), and matrix metalloproteinase-3 (MMP-3) [14][15][16][17][18] . Furthermore, human plasma from the second and third weeks after surgery has been shown to promote endothelial cell (EC) proliferation, invasion, and migration, which are key steps in angiogenesis [14,19] .…”

Plasma interleukin-8 levels are persistently elevated for 1�month after minimally invasive colorectal resection for colorectal cancer

“…Plasma levels of the following proangiogenic proteins have been shown to be persistently increased after minimally invasive colorectal resection (MICR): Vascular endothelial growth factor (VEGF), angiopoeitin-2 (Ang-2), placental growth factor (PIGF), soluble vascular adhesion molecule-1 (sVCAM-1), monocyte chemotactic protein-1 (MCP-1), human chitinase 3-like 1 (Chi3L1), matrix metalloproteinase-3 (MMP-3), and others (11)(12)(13)(14)(15)(16). It has also been shown via in vitro endothelial cell (EC) culture studies that plasma from weeks 2 and 3 after MICR significantly stimulates endothelial cells to proliferate, migrate, and invade when compared to EC culture results obtained with the same patients preoperative plasma (12,17); these EC activities are critical to angiogenesis.…”

Plasma soluble vascular adhesion molecule-1 levels are persistently elevated during the first month after colorectal cancer resection

“…Plasma levels of VEGF, angiopoietin 2 (Ang 2), and placental growth factor (PlGF) have been shown to be elevated significantly for 2-4 weeks after minimally invasive colorectal resection (MICR) for cancer [8,9]. Interestingly, all three proteins play a role in angiogenesis that is critical to both wound healing and tumor growth.…”