2011
DOI: 10.3171/2011.5.jns10505
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Minimally invasive evacuation of spontaneous intracerebral hemorrhage using sonothrombolysis

Abstract: Object Catheter-based evacuation is a novel surgical approach for the treatment of brain hemorrhage. The object of this study was to evaluate the safety and efficacy of ultrasound in combination with recombinant tissue plasminogen activator (rt-PA) delivered through a microcatheter directly into spontaneous intraventricular (IVH) or intracerebral (ICH) hemorrhage in humans. Methods Thirty-three patients presenting to the Swedish Medical Center in Seattle, Washington, with ICH and IVH were screened between No… Show more

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Cited by 92 publications
(67 citation statements)
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“…69 There is also a clinical trial currently underway for endoscopic hematoma evacuation in all-cause ICH (MISTIE-ICES). Most recently, Newell and colleagues 73 used adjuvant sonothrombolysis to attain an average of 59% hematoma reduction at 24 hours following evacuation. Results from these trials will further characterize the possible role of minimally invasive techniques in the surgical treatment of CAA-associated ICH.…”
Section: Minimally Invasive Surgical Techniques For the Treatment Of mentioning
confidence: 99%
“…69 There is also a clinical trial currently underway for endoscopic hematoma evacuation in all-cause ICH (MISTIE-ICES). Most recently, Newell and colleagues 73 used adjuvant sonothrombolysis to attain an average of 59% hematoma reduction at 24 hours following evacuation. Results from these trials will further characterize the possible role of minimally invasive techniques in the surgical treatment of CAA-associated ICH.…”
Section: Minimally Invasive Surgical Techniques For the Treatment Of mentioning
confidence: 99%
“…Most of the available literature is focused on minimal access techniques, such as stereotactic-guided hematoma aspiration and endoscopic clot evacuation, both of which are intended to minimize the disruption of intact brain tissue superficial to the hematoma. 2,12,14,17,20 We believe that although these minimal access techniques might have a role in treating deeper, thalamic, or even brainstem SICH, there are technical advantages to open surgical approaches for putaminal and lobar SICH. The use of open techniques and a microscope allows for more rapid clot decompression and facilitates meticulous hemostasis at the walls of the hematoma cavity.…”
Section: Discussionmentioning
confidence: 99%
“…19 Therefore, many efforts were made to minimize the invasiveness of operative procedures related to clot evacuation. [20][21][22] Driven by recent promising results of DHC in ischemic stroke, DHC could also be promising for treatment of space-occupying ICH. Advantages of DHC include no trauma to brain, ease and speed of the procedure and no issues of brain parenchymal hemostasis.…”
Section: Discussionmentioning
confidence: 99%