Minimally invasive isolated limb perfusion – technical details and initial outcome of a new treatment method for limb malignancies

Bagge, Roger Olofsson; Carlson, P.; Razzazian, R.; Hansson, Christoffer; Hjärpe, Anders; Mattsson, Jan; Katsarelias, Dimitrios

doi:10.1080/02656736.2018.1522000

Cited by 6 publications

(1 citation statement)

References 36 publications

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“…The cannulas are connected to an oxygenated extracorporeal circuit and collateral circulation is controlled by placement of a tourniquet proximally around the extremity. We recently developed a minimally-invasive ILP technique where vascular access is accomplished by percutaneous placement of the catheters by ultrasound and angiography [6].…”

Section: Introductionmentioning

confidence: 99%

Leakage through the bone-marrow during isolated limb perfusion in the lower extremity

Katsarelias

Båth

Carlson

et al. 2019

Journal of Surgical Case Reports

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Isolated limb perfusion (ILP) is used for melanoma in-transit metastases of the extremities. The use of Melphalan and TNF-alpha, necessitates monitoring of possible systemic leakage throughout the perfusion. It has been suspected that leakage through bone marrow is possible. We present the case of a patient with in-transit melanoma metastases in the lower extremity, who underwent minimally invasive ILP, according to our new protocol through percutaneous insertion of the catheters under fluoroscopy. Following cannulation of the vessels a high leakage rate was recorded. The procedure was converted to open with clamping of the artery and vein, however the leakage was not possible to control, and venography showed that this was due to bone marrow veins. To the best of our knowledge this is the first case of a verified leakage during ILP through bone marrow veins. We believe that some minor leakages registered under ILP could be attributed to this leakage route.

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Section: Introductionmentioning

confidence: 99%

Leakage through the bone-marrow during isolated limb perfusion in the lower extremity

Katsarelias

Båth

Carlson

et al. 2019

Journal of Surgical Case Reports

Self Cite

View full text Add to dashboard Cite

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Malignant Melanoma Foot for Isolated Limb Perfusion

Gupta,

Gupta

2024

Problem Based Learning Discussions in Onco-Anesthesia and Onco-Critical Care

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Isolated hyperthermic perfusions for cutaneous melanoma in-transit metastasis of the limb and uveal melanoma metastasis to the liver

Huibers,

DePalo,

Perez

et al. 2023

Clin Exp Metastasis

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Patients with cutaneous melanoma can develop in-transit metastases (ITM), most often localized to limbs. For patients with uveal melanoma that develop metastatic disease, the overall majority develop isolated liver metastases. For these types of metastases, regional cancer therapies have evolved as effective treatments. Isolated limb perfusion (ILP), isolated limb infusion (ILI), isolated hepatic perfusion (IHP) and percutaneous hepatic perfusion (PHP) achieve a high local concentration of chemotherapy with minimal systemic exposure. This review discusses the mechanism and available literature on locoregional treatment modalities in the era of modern immunotherapy.

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Minimally invasive isolated limb perfusion – technical details and initial outcome of a new treatment method for limb malignancies

Abstract: Katsarelias (2018) Minimally invasive isolated limb perfusion-technical details and initial outcome of a new treatment method for limb malignancies,

Cited by 6 publications

References 36 publications

Leakage through the bone-marrow during isolated limb perfusion in the lower extremity

Leakage through the bone-marrow during isolated limb perfusion in the lower extremity

Malignant Melanoma Foot for Isolated Limb Perfusion

Isolated hyperthermic perfusions for cutaneous melanoma in-transit metastasis of the limb and uveal melanoma metastasis to the liver

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