Minimally invasive photoacoustic imaging: Current status and future perspectives

Zhao, Tianrui; Desjardins, Adrien E.; Ourselin, Sébastien; Vercauteren, Tom; Xia, Wenfeng

doi:10.1016/j.pacs.2019.100146

Cited by 115 publications

(80 citation statements)

References 165 publications

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“…PA imaging is emerging as a new noninvasive bioimaging technique based on the detection of ultrasound waves as produced by the light absorption-triggered thermally expanded tissues. [216][217][218][219][220][221] PA imaging features distinctive merits as compared to traditional fluorescence imaging, attributing to its enhanced tissue-penetrating capability. Because the NIR-responsive photothermal nanoagents can induce the tissue expansion by thermal effect, abundant photothermal nanoagents have been developed as the contrast agents for PA bioimaging.…”

Section: Cu-involved Contrast Agents For Bioimagingmentioning

confidence: 99%

The Coppery Age: Copper (Cu)‐Involved Nanotheranostics

et al. 2020

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As an essential trace element in the human body, transitional metal copper (Cu) ions are the bioactive components within the body featuring dedicated biological effects such as promoting angiogenesis and influencing lipid/glucose metabolism. The recent substantial advances of nanotechnology and nanomedicine promote the emerging of distinctive Cu‐involved biomaterial nanoplatforms with intriguing theranostic performances in biomedicine, which are originated from the biological effects of Cu species and the physiochemical attributes of Cu‐composed nanoparticles. Based on the very‐recent significant progresses of Cu‐involved nanotheranostics, this work highlights and discusses the principles, progresses, and prospects on the elaborate design and rational construction of Cu‐composed functional nanoplatforms for a diverse array of biomedical applications, including photonic nanomedicine, catalytic nanotherapeutics, antibacteria, accelerated tissue regeneration, and bioimaging. The engineering of Cu‐based nanocomposites for synergistic nanotherapeutics is also exemplified, followed by revealing their intrinsic biological effects and biosafety for revolutionizing their clinical translation. Finally, the underlying critical concerns, unresolved hurdles, and future prospects on their clinical uses are analyzed and an outlook is provided. By entering the “Copper Age,” these Cu‐involved nanotherapeutic modalities are expected to find more broad biomedical applications in preclinical and clinical phases, despite the current research and developments still being in infancy.

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Section: Cu-involved Contrast Agents For Bioimagingmentioning

confidence: 99%

The Coppery Age: Copper (Cu)‐Involved Nanotheranostics

et al. 2020

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“…We believe that with continued technological development and higher laser energy, the system holds considerable promise for use in clinical cases. Other possibilities to extend this technique to clinical use are the miniaturization of the probes for intracavitary imaging with a mini-invasive approach and developing peroperative exploitation ( 37 ).…”

Section: Discussionmentioning

confidence: 99%

Experimental Myocardial Infarction Elicits Time-Dependent Patterns of Vascular Hypoxia in Peripheral Organs and in the Brain

David

Ughetto

Gaudard

et al. 2021

Front. Cardiovasc. Med.

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Aims: Microvascular alterations occurring after myocardial infarction (MI) may represent a risk factor for multi-organ failure. Here we used in vivo photoacoustic (PA) imaging to track and define the changes in vascular oxygen saturation (sO2) occurring over time after experimental MI in multiple peripheral organs and in the brain.Methods and Results: Experimental MI was obtained in BALB/c mice by permanent ligation of the left anterior descending artery. PA imaging (Vevo LAZR-X) allowed tracking mouse-specific sO2 kinetics in the cardiac left ventricular (LV) anterior wall, brain, kidney, and liver at 4 h, 1 day, and 7 days post-MI. Here we reported a correlation between LV sO2 and longitudinal anterior myocardial strain after MI (r = −0.44, p < 0.0001, n = 96). Acute LV dysfunction was associated with global hypoxia, specifically a decrease in sO2 level in the brain (−5.9%), kidney (−6.4%), and liver (−7.3%) at 4 and 24 h post-MI. Concomitantly, a preliminary examination of capillary NG2DsRed pericytes indicated cell rarefication in the heart and kidney. While the cardiac tissue was persistently impacted, sO2 levels returned to pre-MI levels in the brain and in peripheral organs 7 days after MI.Conclusions: Collectively, our data indicate that experimental MI elicits precise trajectories of vascular hypoxia in peripheral organs and in the brain. PA imaging enabled the synchronous tracking of oxygenation in multiple organs and occurring post-MI, potentially enabling a translational diagnostic modality for the identification of vascular modifications in this disease setting.

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“…Limited by space, we will focus on several important developments that have overcome the longstanding limits in traditional PAT. Interested readers are referred to comprehensive review articles that provide in-depth analyses and discussions on low-cost light sources, 22 , 26 – 28 novel ultrasound sensors, 21 , 29 , 30 PA contrast agents, 29 , 31 , 32 PA endoscopy, 33 , 34 deep learning enhanced PAT, 35 – 37 as well as clinical translation of PAT. 22 , 38 – 41 …”

Section: Technical Advances In Patmentioning

confidence: 99%

Perspective on fast-evolving photoacoustic tomography

Yao

Wang

2021

J. Biomed. Opt.

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: Significance: Acoustically detecting the rich optical absorption contrast in biological tissues, photoacoustic tomography (PAT) seamlessly bridges the functional and molecular sensitivity of optical excitation with the deep penetration and high scalability of ultrasound detection. As a result of continuous technological innovations and commercial development, PAT has been playing an increasingly important role in life sciences and patient care, including functional brain imaging, smart drug delivery, early cancer diagnosis, and interventional therapy guidance. Aim: Built on our 2016 tutorial article that focused on the principles and implementations of PAT, this perspective aims to provide an update on the exciting technical advances in PAT. Approach: This perspective focuses on the recent PAT innovations in volumetric deep-tissue imaging, high-speed wide-field microscopic imaging, high-sensitivity optical ultrasound detection, and machine-learning enhanced image reconstruction and data processing. Representative applications are introduced to demonstrate these enabling technical breakthroughs in biomedical research. Conclusions: We conclude the perspective by discussing the future development of PAT technologies.

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Minimally invasive photoacoustic imaging: Current status and future perspectives

Cited by 115 publications

References 165 publications

The Coppery Age: Copper (Cu)‐Involved Nanotheranostics

The Coppery Age: Copper (Cu)‐Involved Nanotheranostics

Experimental Myocardial Infarction Elicits Time-Dependent Patterns of Vascular Hypoxia in Peripheral Organs and in the Brain

Perspective on fast-evolving photoacoustic tomography

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