A variety of conservative and surgical therapy options are available for the treatment of focal hyperhidrosis. In case of severe therapy-resistant forms, surgery aims to achieve permanent reduction of sweating. For axillary hyperhidrosis, local surgical techniques are the method of choice with minimally-invasive techniques favored in recent years. Sympathectomy is the ultima ratio for palmar hyperhidrosis; however, the procedure can lead to severe side effects. For most surgical techniques for hyperhidrosis, both long-term studies and side-to-side comparisons are not available.