Minimally Invasive Surgical Staging in Early-stage Ovarian Carcinoma: A Systematic Review and Meta-analysis

Bogani, Giorgio; Borghi, Chiara; Maggiore, Umberto Leone Roberti; Ditto, Antonino; Signorelli, Mauro; Martinelli, Fabio; Chiappa, Valentina; López, Carlos; Sabatucci, Ilaria; Scaffa, Cono; Indini, Alice; Ferrero, Simone; Lorusso, Domenica; Raspagliesi, Francesco

doi:10.1016/j.jmig.2017.02.013

Cited by 52 publications

(53 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Over the last ten years, multiple studies have compared survival in ovarian cancer after MIS and OPS without showing any clear differences between the approaches, but each of these studies had a limited sample size. Meta-analyses of ovarian cancer have recently been published [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ] showing similar operative and clinical outcomes between patients treated by MIS and those operated by OPS. However, none of them compared three or five-year survival or performed an overall analysis (early and advanced stages).…”

Section: Introductionmentioning

confidence: 99%

Three and Five-Year Mortality in Ovarian Cancer after Minimally Invasive Compared to Open Surgery: A Systematic Review and Meta-Analysis

Jochum

Vermel

Faller

et al. 2020

JCM

View full text Add to dashboard Cite

As regards ovarian cancer, the use of minimally invasive surgery has steadily increased over the years. Reluctance persists, however, about its oncological outcomes. The main objective of this meta-analysis was to compare the three and five-year mortality of patients operated by minimally invasive surgery (MIS) for ovarian cancer to those operated by conventional open surgery (OPS), as well as their respective perioperative outcomes. PubMed, Cochrane library and CinicalTrials.gov were systematically searched, using the terms laparoscopy, laparoscopic or minimally invasive in combination with ovarian cancer or ovarian carcinoma. We finally included 19 observational studies with a total of 7213 patients. We found no statistically significant difference for five-year (relative risk (RR) = 0.89, 95% CI 0.53–1.49, p = 0.62)) and three-year mortality (RR = 0.95, 95% CI 0.80–1.12, p = 0.52) between the patients undergoing MIS and those operated by OPS. When five and three-year recurrences were analyzed, no statistically significant differences were also observed. Analysis in early and advanced stages subgroups showed no significant difference for survival outcomes, suggesting oncological safety of MIS in all stages. Whether the surgery was primary or interval debulking surgery in advanced ovarian cancer, did not influence the comparative results on mortality or recurrence. Although the available studies are retrospective, and mostly carry a high risk for bias and confounding, an overwhelming consistency of the evidence suggests the likely effectiveness of MIS in selected cases of ovarian cancer, even in advanced stages. To validate the use of MIS, the development of future randomized interventional studies should be a priority.

show abstract

Section: Introductionmentioning

confidence: 99%

Three and Five-Year Mortality in Ovarian Cancer after Minimally Invasive Compared to Open Surgery: A Systematic Review and Meta-Analysis

Jochum

Vermel

Faller

et al. 2020

JCM

View full text Add to dashboard Cite

show abstract

“…Our survey provides support that a segment of the gynecologic oncology community has definite interest in the use of MIS highlighting several perceived benefits of MIS, including reduced patient morbidity and length of hospital stay. Prior studies have documented the safety and efficacy of MIS for staging in presumed early-stage EOC and interval cytoreductive surgery ( Ditto et al, 2017 , Bogani et al, 2017 , Koo et al, 2014 , Gueli Alletti et al, 2016 ). A National Cancer Database case-control study showed no difference in time to death between laparoscopy and laparotomy staging in presumed Stage I EOC ( Melamed et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

“…A number of recent retrospective studies suggest that laparoscopic surgery is feasible and safe for the treatment of early-stage epithelial OC ( Ditto et al, 2017 , Bogani et al, 2017 , Melamed et al, 2017 , Koo et al, 2014 ); as well as advanced-stage EOC, particularly after patients have received NACT ( Melamed et al, 2017 , Gueli Alletti et al, 2016 , Fagotti et al, 2019 ). Although these studies are retrospective in nature and are limited by small sample sizes, they provide data that lends support to the use of MIS for the treatment of OC; however, there is no current consensus on its widespread use.…”

Section: Introductionmentioning

confidence: 99%

Practice patterns using minimally invasive surgery for the treatment of ovarian cancer: A survey of physician members of the Society of Gynecologic Oncologists

Kremer

Lee

Carlson

et al. 2020

Gynecologic Oncology Reports

View full text Add to dashboard Cite

Highlights: Use of MIS for the treatment of early-stage ovarian cancer appears to be common. Gynecologic oncologists show interest in performing advanced laparoscopic procedures. Neoadjuvant chemotherapy may play role in determining use of MIS for ovarian cancer. Barriers to MIS for ovary cancer were concern for occult disease and lack of evidence.

show abstract

“…[ 18 ] A systematic review also showed laparoscopic staging surgery for ovarian cancer showed longer operative time, shorter hospital stay, a short period from surgery to chemotherapy, and equivalent survival than laparotomy. [ 19 ] Another report showed 26 women with early-stage ovarian cancer received laparoscopic staging surgery. They concluded that laparoscopic is a valuable treatment for early-stage ovarian cancer.…”

Section: Discussionmentioning

confidence: 99%

Ovarian Diffuse Large B-cell Lymphoma Initially Suspected Dysgerminoma Managed by Laparoscopic Staging Surgery

Lim

Hsu

et al. 2020

Gynecol Minim Invasive Ther

View full text Add to dashboard Cite

Ovarian diffuse large B-cell lymphoma (DLBCL) is rare. DLBCL is a complex type of lymphoma. The ovarian DLBCL usually harbor a favorable prognosis. We report a case of ovarian DLBCL that presented as an ovarian mass with lower abdominal pain and was managed using laparoscopic staging surgery. A 29-year-old female (gravida 2, para 0, abortion 2) with a history of polycystic ovarian syndrome with irregular medication control visited our clinic due to lower abdominal pain. Transvaginal ultrasound revealed a heterogeneous, septated mass over the left adnexa with a diameter of approximately 6 cm × 8 cm. The tumor marker CA 19-9 was elevated (65.77 IU/mL); CA125 and carcinoembryonic antigen were not elevated. Laparoscopic surgery with left salpingo-oophorectomy was first performed. Frozen section indicated dysgerminoma. Then, we continued staging surgery through bilateral pelvic lymph node dissection, para-aortic lymph node dissection, omentectomy, right ovary and peritoneum biopsy, and washing cytology. Ovarian tumor and para-aortic lymph nodes were positive for lymphoma. The tumor cells were positive staining for CD20, CD5, ki67, BCL-6, and MUM-1, which was associated with DLBCL. The patient was then consulted for oocyte preservation and referred to hematology for further chemotherapy. In conclusion, an ovarian lymphoma is a rare event. The presence of an enlarged ovarian tumor should raise the suspicion of ovarian lymphoma. To differentiate ovarian lymphoma from dysgerminoma, immunohistochemistry is useful. Fertility preservation should be considered before chemotherapy. Ovarian tissue or oocyte preservation or gonadotropin-releasing hormone agonist injection before chemotherapy can be performed for fertility preservation.

show abstract

Minimally Invasive Surgical Staging in Early-stage Ovarian Carcinoma: A Systematic Review and Meta-analysis

Cited by 52 publications

References 26 publications

Three and Five-Year Mortality in Ovarian Cancer after Minimally Invasive Compared to Open Surgery: A Systematic Review and Meta-Analysis

Three and Five-Year Mortality in Ovarian Cancer after Minimally Invasive Compared to Open Surgery: A Systematic Review and Meta-Analysis

Practice patterns using minimally invasive surgery for the treatment of ovarian cancer: A survey of physician members of the Society of Gynecologic Oncologists

Ovarian Diffuse Large B-cell Lymphoma Initially Suspected Dysgerminoma Managed by Laparoscopic Staging Surgery

Contact Info

Product

Resources

About