Minimally Invasive Therapies in the Treatment of Erectile Dysfunction in Anticoagulated Cases: A Study of Satisfaction and Safety

Limoge, Jerome P.; Olins, Eric; Henderson, Diane; Donatucci, Craig F.

doi:10.1016/s0022-5347(01)66241-4

Cited by 32 publications

(14 citation statements)

References 14 publications

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“…This study provides information on the risks and benefits in such a situation. Of note, our data are consistent with studies suggesting the safety of intramuscular (6) and other (7) injections in such patients.…”

Section: Discussionsupporting

confidence: 91%

A prospective study of the safety of joint and soft tissue aspirations and injections in patients taking warfarin sodium

Thumboo

O’Duffy

1998

Arthritis & Rheumatism

109

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Section: Discussionsupporting

confidence: 91%

A prospective study of the safety of joint and soft tissue aspirations and injections in patients taking warfarin sodium

Thumboo

O’Duffy

1998

Arthritis & Rheumatism

109

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“…30 Patients with bleeding disorders or those on anticoagulation therapy are considered at high risk to develop petechiae, eechymosis or hematoma; 7 however, it was shown that the risk did not exceed that of the general population. 31 …”

Section: Contraindicationsmentioning

confidence: 99%

Vacuum therapy in erectile dysfunction—science and clinical evidence

et al. 2010

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Vacuum therapy (VT) utilizes negative pressure to distend the corporal sinusoids and to increase the blood inflow to the penis. Depending on its purpose, VT could be used as vacuum constriction device (VCD), with the aid of an external constricting ring which is placed at the base of penis to prevent blood outflow, maintaining the erection for sexual intercourse. Also, as a vacuum erectile device (VED), without the application of a constriction ring, just increases blood oxygenation to the corpora cavernosa and for other purposes. The emerging of phosphodiesterase 5 inhibitors (PDE 5 I) for the treatment of erectile dysfunction (ED) eclipsed VCD as therapeutic choice for ED; however, widespread usage of VED as part of penile rehabilitation after radical prostatectomy and other purposes rekindle the interest for VT. The underlying hypothesis is that the artificial induction of erections shortly after surgery facilitates tissue oxygenation, reducing cavernosal fibrosis in the absence of nocturnal erections, and potentially increases the likelihood of preserving erectile function. Due to its ability to draw blood into the penis regardless of nerve disturbance, VED has become the centerpiece of penile rehabilitation protocols. Herein, we reviewed the history, mechanism, application, side effects and future direction of VT in ED.

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“…63 In only 11 (1.6%) of 706 documented vacuum applications and three (0.5%) of 605 self-injections, ecchymoses of the penile skin were recorded in patient diaries, indicating that the risk of bleeding, both in vacuum therapy and self-injection therapy, is not higher in the group receiving anticoagulants than it would be in a normal patient population. In the author's clinical practice, following 10 patients treated with the anticoagulant marcoumar for a number of years, no severe bleeding complications have been observed.…”

Section: Calcitonin Gene Related Peptide Combined With Pgementioning

confidence: 96%

Current perspectives on intracavernosal pharmacotherapy for erectile dysfunction

Porst¹

2000

Int J Impot Res

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Thirty percent of males af¯icted with erectile dysfunction (ED) do not respond to oral drugs, another 15% reveal contraindications to currently available therapy, and a subset of patients actually prefer injection therapy due to its predictable short time-to-onset of erection and reliable rigidity compared to oral drugs. This paper provides both a historical and current perspective on intracavernosal therapy and reviews the popular injectable therapeutic agents that are currently used for the treatment of ED. Emphasis is placed on the ef®cacy, mechanism of action and side effect pro®les of approved and experimental injectable pharmacotherapy for ED.

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Minimally Invasive Therapies in the Treatment of Erectile Dysfunction in Anticoagulated Cases: A Study of Satisfaction and Safety

Abstract: The adverse effects of vacuum therapy and intracavernous self-injection in patients on warfarin do not exceed the rate in the general urological population. These therapies appear to be safe in patients receiving warfarin.

Cited by 32 publications

References 14 publications

A prospective study of the safety of joint and soft tissue aspirations and injections in patients taking warfarin sodium

A prospective study of the safety of joint and soft tissue aspirations and injections in patients taking warfarin sodium

Vacuum therapy in erectile dysfunction—science and clinical evidence

Current perspectives on intracavernosal pharmacotherapy for erectile dysfunction

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