Minimally invasive treatment of urethral strictures in men

Latini, Jerilyn M.

doi:10.1007/s11884-008-0017-4

Cited by 9 publications

(7 citation statements)

References 51 publications

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“…Although open urethroplasty is a highly successful and durable treatment method, surgeons don't perform it so often due to its invasiveness, longer catheterization requirement and need of experienced surgery skills (8). The recurrence of stricture occurs as a result of scar that forms into the urethral epithelium and decreases the caliber of urethra (9). There are many investigations about use of drugs such as steroids, Mitomycin C, Hyaluronidsase to avoid this scar or keloid formation (10)(11)(12).…”

mentioning

confidence: 99%

The effectiveness of local steroid injection after internal urethrotomy to avoid recurrence

Yıldırım

Kaynar

Özyuvalı

et al. 2016

Arch Ital Urol Androl

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mentioning

confidence: 99%

The effectiveness of local steroid injection after internal urethrotomy to avoid recurrence

Yıldırım

Kaynar

Özyuvalı

et al. 2016

Arch Ital Urol Androl

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“…5 However, after a single VIU, the long-term cure rates for noneradiationassociated strictures are as low as 30%-40%. 6 In an effort to decrease the rate of urethral stricture recurrence after VIU, supplemental injection of mitomycin C (MMC) has been proposed owing to its ability to mitigate scar formation via inhibition of fibroblast proliferation. 7,8 In the present study, we aim to describe a safe and widely available endoscopic alternative to open surgical reconstruction that is more durable than VIU alone in patients with recalcitrant urethral strictures and bladder neck contractures (BNC) of various etiologies.…”

mentioning

confidence: 99%

Visual Internal Urethrotomy With Intralesional Mitomycin C and Short-term Clean Intermittent Catheterization for the Management of Recurrent Urethral Strictures and Bladder Neck Contractures

Farrell

Sherer

Levine

2015

Urology

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“…Compared with other methods, DVIU had been considered as standard therapy for anterior urethral strictures since its introduction in 1974 [43]. However, the efficiency of DVIU is still doubted due to the high recurrence risk of a urethral stricture after long-term follow-up [44]. The stricture-free rate after the first DVIU procedure has been reported as 29.66% with a median recurrence time of 8.5 months, and this rate increases with prolonged follow-up [45].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Mitomycin C Combined with Direct Vision Internal Urethrotomy for Urethral Strictures: A Systematic Review and Meta-Analysis

Xu¹,

Zhu²,

Lin³

et al. 2021

Urol Int

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Background: The high recurrence of a urethral stricture after direct vision internal urethrotomy (DVIU) has been a problem for years. Mitomycin C (MMC) is an excellent antifibrosis antigen that has been used in many fields, but its effect on a urethral stricture remains controversial. The purpose of this review was to investigate the effectiveness of MMC in reducing the recurrence rate of a urethral stricture after the first urethrotomy. Methods: Common databases were searched for publications prior to November 30, 2020. Randomized controlled and cohort trials were all included. Recurrence and success rates after the first urethrotomy of the posterior urethra were the main outcomes. Revman 5.3 was used for statistical analysis. Two evaluation systems, the Cochrane risk of bias tool and the Newcastle Ottawa Scale, were used to examine the risk of bias for RCTs and all studies. The quality of evidence was assessed by the Grading of Recommendations, Assessment, Development, and Evaluation standard. Results: Sixteen trials were included, the reporting quality of which was generally poor, and the evidence level was very low to moderate. The addition of MMC could significantly reduce the recurrence rate of urethral strictures (risk ratio [RR] = 0.42; 95% confidence interval [CI]: 0.26, 0.67; p = 0.0002; 9 trials; 550 participants). The results of the subgroup analysis suggested that the effect of MMC combined with DVIU was significant in short (≤2 cm) anterior urethral strictures (RR = 0.39; 95% CI: 0.20, 0.78; p = 0.008), >12-month follow-up (RR = 0.45; 95% CI: 0.26, 0.76; p = 0.003). It also increased the success rate of the first urethrotomy procedure for posterior urethral contracture (RR = 0.74; 95% CI: 0.65, 0.84; p < 0.00001; 7 trials; 342 participants). Low-dose local injection of MMC was the most commonly used method. Conclusion: MMC combined with DVIU is a promising way to reduce the long-term recurrence rate of a short-segment anterior urethral stricture. It also increases the success rate of the first urethrotomy of the posterior urethra. However, more high-quality randomized controlled trials are needed.

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Minimally invasive treatment of urethral strictures in men

Cited by 9 publications

References 51 publications

The effectiveness of local steroid injection after internal urethrotomy to avoid recurrence

The effectiveness of local steroid injection after internal urethrotomy to avoid recurrence

Visual Internal Urethrotomy With Intralesional Mitomycin C and Short-term Clean Intermittent Catheterization for the Management of Recurrent Urethral Strictures and Bladder Neck Contractures

Efficacy of Mitomycin C Combined with Direct Vision Internal Urethrotomy for Urethral Strictures: A Systematic Review and Meta-Analysis

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