Minimally Invasive Tubular Approach for Occipital Condylar Biopsy and Resection: Case Report and Review of Literature

Platt, Andrew; Stamates, Melissa M.; Wong, Ricky H.

doi:10.1016/j.wneu.2020.02.066

Cited by 3 publications

(4 citation statements)

References 22 publications

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“…described a condylar resection performed with a tubular retractor system. 16 Rodriguez-Pardo et al. described two patients who underwent occipital condyle biopsy within a systematic review involving 35 cases of patients with isolated OCS.…”

Section: Discussionmentioning

confidence: 99%

“…Teranishi et al performed a biopsy of an occipital condyle using a 3 cm incision and optical tracking navigation, 15 while Platt et al described a condylar resection performed with a tubular retractor system. 16 Rodriguez-Pardo et al described two patients who underwent occipital condyle biopsy within a systematic review involving 35 cases of patients with isolated OCS. 4 Nevertheless, the exact method was not explained in either case.…”

Section: Discussionmentioning

confidence: 99%

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Trans-oral approach for occipital condyle biopsy: Case report and review of literature

et al. 2021

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Isolated occipital condyle lesions are commonly treated with empirical radiation, with the sole aim of relieving symptoms. Patients rarely undergo surgical biopsy, considering the morbidity associated with open surgery approaches and the importance of surrounding structures limiting the application of computed tomography (CT) scan or fluoroscopic percutaneous needle biopsies. We describe the case of a 66-year-old woman who was admitted on an emergency basis. Her clinical presentation included unilateral occipital headache and ipsilateral hypoglossal nerve palsy. Imaging revealed findings consistent with an isolated right occipital condyle lesion. In order to pursue a tissue diagnosis, essential to dictate medical management accurately, a minimally invasive biopsy of the occipital condyle through the trans-oral route was performed. Combined fluoroscopy, cone-bean CT and angiography allowed safe access to the lesion.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Trans-oral approach for occipital condyle biopsy: Case report and review of literature

et al. 2021

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“…Afterward, the tumor cells in the bone tissue were observed by SEM. (2) The other bones were incubated with DMEM supplemented with 70 μg/mL NR for 1 h under standard culture conditions. In this live bone culture approach, NR was rapidly taken up by osteoclasts [31].…”

Section: Antitumor Antiosteoclastogenic and Anti-bone Resorption Acti...mentioning

confidence: 99%

“…Patients with breast cancer frequently suffer from metastatic relapse months to decades after the initial diagnosis and treatment, which dramatically decreases their life expectancy. The organ in which breast cancer metastasis most commonly occurs is bone [ 2 ], with bone metastasis secondary to breast cancer occurring in approximately 70% of patients with advanced disease [ 3 ]. Bone metastases are generally osteolytic, as cancer cells obstruct the normal bone remodeling process and enhance osteoclast-mediated bone resorption [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Dual ligand-targeted Pluronic P123 polymeric micelles enhance the therapeutic effect of breast cancer with bone metastases

GAO,

ZHANG,

KLEIJN

et al. 2024

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Bone metastasis secondary to breast cancer negatively impacts patient quality of life and survival. The treatment of bone metastases is challenging since many anticancer drugs are not effectively delivered to the bone to exert a therapeutic effect. To improve the treatment efficacy, we developed Pluronic P123 (P123)-based polymeric micelles dually decorated with alendronate (ALN) and cancer-specific phage protein DMPGTVLP (DP-8) for targeted drug delivery to breast cancer bone metastases. Doxorubicin (DOX) was selected as the anticancer drug and was encapsulated into the hydrophobic core of the micelles with a high drug loading capacity (3.44%). The DOX-loaded polymeric micelles were spherical, 123 nm in diameter on average, and exhibited a narrow size distribution. The in vitro experiments demonstrated that a pH decrease from 7.4 to 5.0 markedly accelerated DOX release. The micelles were well internalized by cultured breast cancer cells and the cell death rate of micelle-treated breast cancer cells was increased compared to that of free DOX-treated cells. Rapid binding of the micelles to hydroxyapatite (HA) microparticles indicated their high affinity for bone. P123-ALN/DP-8@DOX inhibited tumor growth and reduced bone resorption in a 3D cancer bone metastasis model. In vivo experiments using a breast cancer bone metastasis nude model demonstrated increased accumulation of the micelles in the tumor region and considerable antitumor activity with no organ-specific histological damage and minimal systemic toxicity. In conclusion, our study provided strong evidence that these pH-sensitive dual ligand-targeted polymeric micelles may be a successful treatment strategy for breast cancer bone metastasis.

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Minimally invasive surgical techniques for intracranial tumour lesions in paediatric neurosurgery: state of art

Safronova¹,

Kushel²

2022

Bulletin of Neurology, Psychiatry and Neurosurgery

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After a long way of evolution in neurosurgical and intensive care technologies the high-end surgeries have become less challenging and survival rate has improved significantly. Planning a tumour surgery today means not only achieving a total removal but finding a less traumatic strategy that would not decrease quality of the patient’s life. A significant experience of using keyhole surgery, endoscopic assistance, and portal surgery has been obtained in paediatric department of Burdenko Neurosurgical Centre. This literature review is designed to reveal the current state of minimally invasive technologies for transcranial surgery of intraaxial tumours. Representation of the problem demanded a review of publications including original articles and systematic reviews over the last 10 years and some milestone publications.

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Minimally Invasive Tubular Approach for Occipital Condylar Biopsy and Resection: Case Report and Review of Literature

Cited by 3 publications

References 22 publications

Trans-oral approach for occipital condyle biopsy: Case report and review of literature

Trans-oral approach for occipital condyle biopsy: Case report and review of literature

Dual ligand-targeted Pluronic P123 polymeric micelles enhance the therapeutic effect of breast cancer with bone metastases

Minimally invasive surgical techniques for intracranial tumour lesions in paediatric neurosurgery: state of art

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