Minimization of Local and Systemic Adverse Effects of Topical Glucocorticoids by Nanoencapsulation: In Vivo Safety of Hydrocortisone–Hydroxytyrosol Loaded Chitosan Nanoparticles

Siddique, Muhammad Irfan; Katas, Haliza; Amin, Mohd Cairul Iqbal Mohd; Ng, Shiow Fern; Zulfakar, Mohd Hanif; Buang, Fhataheya; Jamil, Adawiyah

doi:10.1002/jps.24666

Cited by 42 publications

(21 citation statements)

References 53 publications

(50 reference statements)

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“…DOX itself is a well-known anticancer agent that triggers tumor resistance and cardiotoxicity during chemotherapy. Its selectivity towards carcinogenic and non-carcinogenic cells is low [39], however, and ultimately, improved selectivity of nanoformulations, potentially by adding additional cell targeting functionalities [47,48], should be demonstrated. DOX is usually administered intravenously, but nanoparticles can be administered intravenously or through the pulmonary route in liquid or powder form.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of cytotoxicity profile and intracellular localisation of doxorubicin-loaded chitosan nanoparticles

Souto

Farhane²,

Casey³

et al. 2016

Anal Bioanal Chem

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Section: Discussionmentioning

confidence: 99%

Evaluation of cytotoxicity profile and intracellular localisation of doxorubicin-loaded chitosan nanoparticles

Souto

Farhane²,

Casey³

et al. 2016

Anal Bioanal Chem

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“…Ng et al showed that fresh freeze-dried olive (containing around 3% hydroxytyrosol), delivered topically via an arginine bilayer film, could reduce arthritic scores, histological scores, paw and ankle circumferences and circulating interleukin-6 in a rat model of rheumatoid arthritis, induced by Freund’s adjuvant [ 124 ]. A topical formulation of hydrocortisone–hydroxytyrosol loaded chitosan nanoparticles has been developed to treat dermatitis [ 125 ]. Hydroxytyrosol loaded in an emulsion system could be delivered orally to enhance its bioavailability [ 126 ].…”

Section: Perspectives On the Use Of Olive And Its Derivatives In Cmentioning

confidence: 99%

Therapeutic Effects of Olive and Its Derivatives on Osteoarthritis: From Bench to Bedside

Chin

Pang

2017

Nutrients

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Osteoarthritis is a major cause of morbidity among the elderly worldwide. It is a disease characterized by localized inflammation of the joint and destruction of cartilage, leading to loss of function. Impaired chondrocyte repair mechanisms, due to inflammation, oxidative stress and autophagy, play important roles in the pathogenesis of osteoarthritis. Olive and its derivatives, which possess anti-inflammatory, antioxidant and autophagy-enhancing activities, are suitable candidates for therapeutic interventions for osteoarthritis. This review aimed to summarize the current evidence on the effects of olive and its derivatives, on osteoarthritis and chondrocytes. The literature on animal and human studies has demonstrated a beneficial effect of olive and its derivatives on the progression of osteoarthritis. In vitro studies have suggested that the augmentation of autophagy (though sirtuin-1) and suppression of inflammation by olive polyphenols could contribute to the chondroprotective effects of olive polyphenols. More research and well-planned clinical trials are required to justify the use of olive-based treatment in osteoarthritis.

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“…Such nanovectors gave reduced side effects, increased efficiency of delivery, antibacterial properties and enhanced transepidermal penetration. Moreover, Siddique et al [108] produced HC-HT co-loaded chitosan nanoparticles (HC-HT CSNPs) of 235 nm in size and with zeta potential +39.2 mV incorporated into aqueous cream (vehicle) to treat atopic dermatitis. This formulation was investigated in vivo, in albino Wistar rats, for acute dermal toxicity, dermal irritation and repeated dose toxicity.…”

Section: Carbohydrate Matrixmentioning

confidence: 99%

“…Magnetic bovine serum albumin (BSA) nanoparticles [105] Carbohydrate matrix Chitosan nanoparticles [106] Chitosan nanoparticles incorporated into an aqueous cream [107,108] Polyester nanoparticles mPEG-PLGA nanoparticles [109] Cyclodextrins β-CD [110] HP-β-CD [111] Micelles whey protein concentrate (WPC) and pectin complexes [112] acidic or neutral pH and slightly soluble under alkali conditions. For another CU is unstable in the gut and trace amounts of curcumin that pass through the gastrointestinal tract are rapidly degraded [118].…”

Section: Serum Albumin Nanoparticlesmentioning

confidence: 99%

Polyphenols Nanoencapsulation for Therapeutic Applications

A¹

2016

J Biomol Res Ther

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Natural polyphenols are valuable compounds present in plants, fruits, legumes, chocolate, tea, wine and marine organisms possessing scavenging properties towards radical oxygen species. These abilities make polyphenols interesting either for the treatment of various diseases like inflammation and cancer or for anti-ageing purposes in cosmetic formulations. Unfortunately, such compounds lack in long-term stability, are very sensitive to light, and often present a low water solubility and poor bioavailability. To overcome these limitations and enhance polyphenols therapeutic applications, nanotechnology-based delivery systems have been developed, and among all, nanoencapsulation represented a promising strategy. This review described a recent overview of physicochemical nanoencapsulated polyphenols focusing on the most representative molecules such as resveratrol, quercetin, epigallocatechin-3-gallate, and curcumin.

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Minimization of Local and Systemic Adverse Effects of Topical Glucocorticoids by Nanoencapsulation: In Vivo Safety of Hydrocortisone–Hydroxytyrosol Loaded Chitosan Nanoparticles

Cited by 42 publications

References 53 publications

Evaluation of cytotoxicity profile and intracellular localisation of doxorubicin-loaded chitosan nanoparticles

Evaluation of cytotoxicity profile and intracellular localisation of doxorubicin-loaded chitosan nanoparticles

Therapeutic Effects of Olive and Its Derivatives on Osteoarthritis: From Bench to Bedside

Polyphenols Nanoencapsulation for Therapeutic Applications

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