Minimized extracorporeal circulation: physiology and pathophysiology

Dimarakis, Ioannis; Joshi, Vijay V.; Hesford, W.; Asimakopoulos, Georgios

doi:10.1533/9780857096029.1.35

Cited by 2 publications

(1 citation statement)

References 36 publications

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“…We evaluated three biomarkers for cardiovascular disease: Creatine Kinases (CK), Cardiac Troponin I (CTN-I), and Natriuretic Peptides (NPs). These indicators help diagnose and treat different cardiac conditions 24 . CK fuels the brain, heart, and skeletal muscles.…”

Section: Introductionmentioning

confidence: 99%

<i>Apium graveolens</i> Aqueous Extract Reduced Cardiovascular Diseases and Inflammatory Biomarkers Expression in High-Fat Diet-Fed BALB/C Mice

Marbaniang,

Sharan,

Kma

2023

JNR

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Background and Aims: Cardiovascular disease prevention has always been a high goal. The goal of this study is to investigate if Apium graveolens has any influence on cardiovascular disease risk factors, biomarkers, and inflammatory biomarkers in male BALB/c mice that have been given a high-fat diet. Methods: Apium graveolens aqueous extract was given to male BALB/c mice, and they were either fed a standard pellet or a diet composed of cholesterol (0.15%), sodium cholate (0.5%), and pure coconut oil (21%) for 12 weeks. Serum fasting glucose, a lipid profile, liver function tests, and cardiac indicators were used to evaluate the extract’s anti-dyslipidemic, hypoglycemic, hepatoprotective, and cardioprotective characteristics. Antioxidant enzyme markers in tissues were also evaluated. To evaluate inflammatory and CVD biomarkers in cardiac tissue, RT-qPCR and ELISA were used. An unpaired t-test assessed group differences. P < 0.05 showed significance. Results: The HFD control group exhibited considerably higher levels of blood glucose, lipid profile, hepatic indicators, inflammatory and cardiac markers, and lower levels of HDL-C and antioxidant enzymes. When administered orally, an aqueous extract of Apium graveolens significantly reduced blood glucose levels. Serum lipids and liver indicators returned to nearnormal levels. In addition to a considerable reduction in MDA levels, treated mice showed a large increases in catalase and reduced glutathione activities. Inflammatory and cardiovascular disease biomarker expression was reduced in the extract-treated groups. Conclusions: Apium graveolens consumption may help reduce the risk of cardiovascular disorders.

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Section: Introductionmentioning

confidence: 99%

<i>Apium graveolens</i> Aqueous Extract Reduced Cardiovascular Diseases and Inflammatory Biomarkers Expression in High-Fat Diet-Fed BALB/C Mice

Marbaniang,

Sharan,

Kma

2023

JNR

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Enzymes as indispensable markers in disease diagnosis

Pathan,

Kharwar,

Ibrahim

et al. 2024

Bioanalysis

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Enzymes have been used for disease diagnosis for many decades; however, advancements in technology like ELISA and flow cytometry-based detection have significantly increased their use and have increased the sensitivity of detection. Technological advancements in recombinant enzyme production have increased enzymatic stability, and the use of colorimetric-based and florescence-based assays has led to their increased use as biomarkers for disease detection. Enzymes like acid phosphatase, cathepsin, lactate dehydrogenase, thymidine kinase and creatine kinase are indispensable markers for diagnosing cancer, cardiovascular diseases and others. This minireview summarizes various enzymes used in disease diagnosis, their metabolic role, market value and potential as disease markers across various metabolic and other disorders.

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Minimized extracorporeal circulation: physiology and pathophysiology

Cited by 2 publications

References 36 publications

<i>Apium graveolens</i> Aqueous Extract Reduced Cardiovascular Diseases and Inflammatory Biomarkers Expression in High-Fat Diet-Fed BALB/C Mice

<i>Apium graveolens</i> Aqueous Extract Reduced Cardiovascular Diseases and Inflammatory Biomarkers Expression in High-Fat Diet-Fed BALB/C Mice

Enzymes as indispensable markers in disease diagnosis

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