2024
DOI: 10.1093/nsr/nwae135
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Minimizing the ratio of ionizable lipid in lipid nanoparticles for in vivo base editing

Qiubing Chen,
Xuebin Wang,
Yizhou Zhang
et al.

Abstract: Lipid nanoparticles have gained clinical approval as carriers for both siRNA and mRNA. Among the crucial components of LNPs, ionizable lipids play a pivotal role in determining the efficiency of RNA delivery. In this study, we synthesized a series of ionizable lipids, denoted as HTO, with a higher count of hydroxyl groups compared to SM-102. Remarkably, LNPs based on HTO12 lipid demonstrated comparable mRNA delivery efficiency and biosafety to those based on SM-102. However, the former reduced the ratio of ion… Show more

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