Minimum Alveolar Concentration-Awake of Sevoflurane is Decreased in Patients with Parkinson’s Disease: An Up-and-Down Sequential Allocation Trial

Yang, Cheng‐Wei; Kang, Fang; Meng, Wenjun; Dong, Mei-rong; Huang, Xiang; Wang, Sheng; Zuo, Zhiyi; Li, Juan

doi:10.2147/cia.s291656

Cited by 1 publication

(2 citation statements)

References 34 publications

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“…The sample size was determined based on previous studies 14–16 using the up-and-down method. In each group, the study ended when the number of crossovers from negative to positive responses reached 7.…”

Section: Methodsmentioning

confidence: 99%

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Median Effective Concentration of Ropivacaine for Femoral Nerve Block Maintaining Motor Function During Knee Arthroscopy in Two Age Groups

Tai¹,

Wang²,

Zhao³

et al. 2022

JPR

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Background Femoral nerve block combined with general anesthesia is commonly used for patients undergoing knee arthroscopy in ambulatory care centers. An ideal analgesic agent would selectively (differentially) block sensory fibers, with little or no effect on motor nerves. Ropivacaine is considered to cause less motor block than others. This study investigated the median effective concentration (EC 50 ) of ropivacaine for differential femoral nerve block in adults either younger or older than 60 years. Methods Patients with American Society of Anesthesiologists physical status I–III and scheduled for knee arthroscopy were categorized as 18- to 60-years-old (Group 1), or older than 60 years (Group 2). Surgeries were performed under general anesthesia combined with femoral nerve block via 22 mL ropivacaine. The EC 50 of ropivacaine for differential femoral nerve block was determined using the up-and-down method and probit regression. The primary outcome was the EC 50 (95% confidence interval [CI]) of the 2 groups. Data on the sensory block, analgesic effect, complications, and hemodynamics during surgery were also recorded. Results The EC 50 of 22 mL ropivacaine for differential femoral nerve block of Group 1 (0.124%, 95% CI 0.097–0.143%) was significantly higher than that of Group 2 (0.088%, 95% CI 0.076–0.103%). The sensory block and hemodynamic data of the 2 groups were comparable. None of the patients experienced neurological complications. Conclusion The EC 50 of ropivacaine administered for differential femoral nerve block during knee arthroscopy was lower in patients older than 60 years, relative to younger adults.

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Section: Methodsmentioning

confidence: 99%

“…The sample size was determined based on previous studies 14–16 (7 crossovers from negative to positive responses). Additional analyses were performed with PASS 2021 software to confirm the statistical power of the sample size.…”

Section: Methodsmentioning

confidence: 99%