“… 29 , 30 Indeed, the BCD design has been applied in anesthetic dose-finding studies for other peripheral nerve blocks. 22 , 31 Due to the only MEC 50 of local anesthetics for Dixon and Massy methods, while the BCD up-and-down method could achieve MEC 90 , MEC 95 , or even MEC 99 , those results are more accurate and reliable. Given the small sample size of our present study, further research and larger sample size to explore the differences will enrich our knowledge.…”