Abstract. We established a Complex Systems Digital Campus(CS-DC) e-laboratory "Open Systems Exploration for Ecosystems Leveraging" in view of redesigning sustainable social-ecological systems related to food production ranging over food, health, community, economy, and environment. 6 projects have begun to collaborate in e-laboratory, namely Synecoculture, P2P Food Lab, Open Systems Data Analytics, The Bee Laboratory, Open Systems Simulation and One-Health Food Lab. As a transversal methodology we apply open systems science to deepen scientific understanding and for a continuous amelioration of the management. The projects involve scientists, engineers, artists, citizens and are open to collaboration inside and outside of the e-laboratory. This article summarizes foundational principles of these projects and reports initial steps in operation.