Background: Transforaminal Endoscopic Lmbar Discectomy (TELD) is widely applied for lumbar degenerative disease(LDD) and satisfactory short-term outcomes have been achieved. However, the mid-term and long-term follow-up of this technique is still lacking.Objective: To retrospectively analyze the mid-term clinical efficacy of TELD for single-level LDD with a minimum of 6-year follow-up.Methods: 75 patients with single-level LDD (lumbar disc herniation, lumbar spinal stenosis) who underwent TELD in our department from December 2014 to December 2015 were observed.Visual analog scale (VAS), Japanese Orthopaedic Association evaluation treatment (JOA) score and Oswestry Disability Index (ODI) were calculated and compared before operation, 3 months after operation, 6 months after operation, 1 year after operation and at the last follow-up. Disc Height (DH), disc range of motion (ROM) and disc degeneration on standard lumbar lateral radiographs before operation and at the last follow-up were determined. Recurrence rate and operation-related complications during follow-up were recorded.Results: 64 cases were included and followed up for 6.4±0.1 years. There were no complications such as infection, epidural hematoma and nerve root injury. There were significant differences in VAS, JOA, ODI between preoperative and postoperative 3 months, 6 months, 1 year and last follow-up (P < 0 01), VAS, JOA, ODI at 3 months after operation were different from 6 months after operation (P < 0 05), and there were significant differences compared with preoperative, 1 year after operation and last follow up (P < 0 01). VAS, JOA and ODI at 6 months after operation were significantly different from those before operation (P < 0.01), but not significantly different from those at 1 year after operation and the last follow-up (P > 0.05). There was no significant difference in DH,ROM and the Pfirrmann grade of intervertebral disc preoperative and the last follow-up. During the follow-up period, 3 patients (4.69%) were recurrent, 1 patient (1.67%) found dural rupture and cauda equina hernia, 13 patients (20.31%) had various degrees of POD, and 3 patients (4.69%) had various degrees of muscle weakness.Conclusion: TELD has a satisfactory mid-term efficacy, and has no significant effect on the DH, the stability of the intervertebral disc space, or on intervertebral disc degeneration. However, as expected, TELD was associated with some complications including recurrent disc herniation and POD.