Mining and analysis of adverse drug reactions associated with perampanel based on FAERS database

Liu, Pengcheng; Zhang, Yuwei; Xu, Xiaoli; Zhou, Ming; Yi, Fei; Zhang, Liming

doi:10.1016/j.yebeh.2023.109283

Cited by 5 publications

(6 citation statements)

References 51 publications

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“…It is known that carbamazepine, a potent anticonvulsant used to treat partial and tonic-clonic seizures, can induce granuloma formation and cholestatic and hepatocellular damage in the liver [11][12][13][14][15][16][17][18][19]. In addition, the FDA approved the AMPA antagonist antiepileptic drug perampanel in 2012 [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Even though it undergoes hepatic biotransformation, few studies assess its hepatotoxicity [21].…”

Section: Resultsmentioning

confidence: 99%

“…Epilepsy is typically treated with pharmaceuticals. The therapeutic efficacy can be improved by combining the proper drugs [4].…”

Section: Introductionmentioning

confidence: 99%

“…This medication holds the distinction of being the initial orally administered AMPA antagonist, and it is prescribed for either monotherapy or adjunctive therapy in the management of primary generalized tonic-clonic or focal seizures [8,9]. Perampanel has gained significant attention and investigation in several neurological disorders, including epilepsy, Parkinson's disease, and amyotrophic lateral sclerosis, due to its potential broad-spectrum features, minimal interaction with other antiepileptic drugs, and favorable clinical and economic outcomes [4]. On the other hand, Perampanel is a newgeneration antiepileptic utilized in the adjunctive treatment of partial onset, primary generalized tonicclonic seizures in patients aged 12 and older [10].…”

Section: Introductionmentioning

confidence: 99%

“…Because clinical trials have limitations such as (1) small sample size; (2) short observation time; (3) exclusion of special populations; (4) strict control of the patient's condition or medication regimens; and (5) limitations of observed indicators, post-marketing safety research is critical. However, only some Perampanel safety studies are based on large-scale post-market real-world data [4].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of in vitro hepatotoxicity of perampanel in comparison with carbamazepine: old versus new

Farmanlı,

Ilgın,

Ergun

et al. 2023

Eur J Life Sci

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Since the liver metabolizes many drugs, including antiepileptics, this organ is the main target of drug-induced damage. There is very little data on hepatotoxicity due to carbamazepine and perampanel metabolized in the liver. The available data are based solely on published case reports. For this reason, this study aims to evaluate the hepatotoxicity of carbamazepine and perampanel, which are frequently used in treating epilepsy and which do not have a detailed investigation, although they are suspected of hepatotoxicity. Hepatotoxicity in the HepG2 cell line, IC50 values were calculated by MTT cytotoxicity test, followed by determination of apoptosis/necrosis, various biochemical analyzes (ALT, AST, urea), which is currently a biomarker for liver injury, and hepatotoxicity by ROS and GSH determination. Both drugs increased liver biomarkers, oxidative stress, and cytotoxicity in HepG2 cells. The investigation found that the drugs triggered liver apoptosis, not necrosis. In conclusion, Perampanel may have hepatotoxicity similar to carbamazepine.

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Section: Resultsmentioning

confidence: 99%

“…Epilepsy is typically treated with pharmaceuticals. The therapeutic efficacy can be improved by combining the proper drugs [4].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of in vitro hepatotoxicity of perampanel in comparison with carbamazepine: old versus new

Farmanlı,

Ilgın,

Ergun

et al. 2023

Eur J Life Sci

View full text Add to dashboard Cite

show abstract

“…A series of studies have compared the performance of different signal detection methods 4,[11][12][13][14][15] However, these previous studies have two notable limitations and are unable to provide effective guidance for the optimum selection of signal detection method. First, each of these previous studies only compared a small number of signal detection methods, and thus they were unable to summarize the characteristics and application scopes of all available signal detection methods.…”

Section: Introductionmentioning

confidence: 99%

Adverse drug reaction signal detection methods in spontaneous reporting system: A systematic review

Jiao,

Pu,

Lan

et al. 2024

Pharmacoepidemiology and Drug

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BackgroundA series of signal detection methods have been developed to detect adverse drug reaction (ADR) signals in spontaneous reporting system. However, different signal detection methods yield quite different signal detection results, and we do not know which method has the best detection performance. How to choose the most suitable signal detection method is an urgent problem to be solved. In this study, we systematically reviewed the characteristics and application scopes of current signal detection methods, with the goal of providing references for the optimization selection of signal detection methods in spontaneous reporting system.MethodsWe searched six databases from inception to January 2023. The search strategy targeted literatures regarding signal detection methods in spontaneous reporting system. We used thematic analysis approach to summarize the advantages, disadvantages, and application scope of each signal detection method.ResultsA total of 93 literatures were included, including 27 reviews and 66 methodological studies. Moreover, 31 signal detection methods were identified in these literatures. Each signal detection method has its inherent advantages and disadvantages, resulting in different application scopes of these methods.ConclusionOur systematic review finds that there are variabilities in the advantages, disadvantages, and application scopes of different signal detection methods. This finding indicates that the most suitable signal detection method varies across different drug safety scenarios. Moreover, when selecting signal detection method in a particular drug safety scenario, the following factors need to be considered: purpose of research, database size, drug characteristics, adverse event characteristics, and characteristics of the relations between drugs and adverse events.

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An observational study on the safety of teprotumumab based on FAERS database

Wang,

Xu,

Zhou

et al. 2024

Endocrine

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Mining and analysis of adverse drug reactions associated with perampanel based on FAERS database

Cited by 5 publications

References 51 publications

Evaluation of in vitro hepatotoxicity of perampanel in comparison with carbamazepine: old versus new

Evaluation of in vitro hepatotoxicity of perampanel in comparison with carbamazepine: old versus new

Adverse drug reaction signal detection methods in spontaneous reporting system: A systematic review

An observational study on the safety of teprotumumab based on FAERS database

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