Mining Exosomal Genes for Pancreatic Cancer Targets

Narayanan, Ramaswamy

doi:10.21873/cgp.20028

Cited by 22 publications

(20 citation statements)

References 67 publications

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“…Secreted proteins are involved in a variety of physiological processes like immune response, blood coagulation, digestion, cell signaling and cell communication, and include hormones, proteases and digestive enzymes, immunoregulatory cytokines/chemokines and growth factors 17. Non-protein compounds, such as DNAs, RNAs, and lipids, as well as proteins, can be exported by exosomes 1, 18, 19 and mediate important intercellular signaling pathways 20, which may influence local and even distant microenvironments 21.…”

Section: The Secretomementioning

confidence: 99%

Cellular Interactions in the Tumor Microenvironment: The Role of Secretome

Cunha¹,

Domingos²,

Stefanini³

et al. 2019

J. Cancer

100

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Over the past years, it has become evident that cancer initiation and progression depends on several components of the tumor microenvironment, including inflammatory and immune cells, fibroblasts, endothelial cells, adipocytes, and extracellular matrix. These components of the tumor microenvironment and the neoplastic cells interact with each other providing pro and antitumor signals. The tumor-stroma communication occurs directly between cells or via a variety of molecules secreted, such as growth factors, cytokines, chemokines and microRNAs. This secretome, which derives not only from tumor cells but also from cancer-associated stromal cells, is an important source of key regulators of the tumorigenic process. Their screening and characterization could provide useful biomarkers to improve cancer diagnosis, prognosis, and monitoring of treatment responses.

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Section: The Secretomementioning

confidence: 99%

Cellular Interactions in the Tumor Microenvironment: The Role of Secretome

Cunha¹,

Domingos²,

Stefanini³

et al. 2019

J. Cancer

100

View full text Add to dashboard Cite

show abstract

“…aberrant methylation of CDH1) and alterations in DNA-repair genes (i.e., inactivating mutations of MLH1) are also common (42), while a recent study, using a mouse model of PDAC, identified the transcription factor, RUNX3, as an inducer of metastasis in PDAC (43). Despite this, biomarkers of PDAC remain elusive, although in a recent study, exosomes, extracellular vesicles believed to play a crucial role in pancreatic cancer progression and chemoresistance (44), were found to represent a potentially important resource for identifying therapeutic targets and tools for treating pancreatic cancer (45).…”

Section: Discussionmentioning

confidence: 99%

In Vitro Elucidation of Drug Combination Synergy in Treatment of Pancreatic Ductal Adenocarcinoma

Bush

Boichard

Tsigelny

2018

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“…As a screening process, EV testing can allow for the detection of a cancer prior to presentation. This offers the opportunity for earlier diagnosis and better prognosis for patients which have highly lethal and late presenting cancers, such as pancreatic cancer [91] and NSCLC [92]. It is through examination of EV marker proteins and tumour specific marker proteins across different cancer tissues, that the merits of EV study for disease diagnosis become evident [18].…”

Section: Diagnostic Uses Of Evsmentioning

confidence: 99%

“…Considering the presence of specific EV miRNAs and lncRNAs, a panel of pancreatic cancer specific EV biomarkers could potentially be developed for diagnostic purposes. Also, it can display in which biological samples there are the highest numbers of EV transcripts, which could help direct potential diagnostic avenues to be investigated in the future [91].…”

Section: Diagram Showing Examples Of Ev Sites Of Action In the Humamentioning

confidence: 99%

Origins to Outcomes: A Role for Extracellular Vesicles in Precision Medicine

Prina‐Mello

Maguire

Savage

2018

PRNANO

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Extracellular vesicles (EVs) are of great interest in biological research, and though they are a relatively recent discovery, they have rapidly shown great potential for use in clinical applications. The various techniques used in EV isolation along with their respective strengths, weaknesses, and potential for downstream applications are outlined here. A brief description of the different approaches in exosome characterisation are subsequently described. It has been highlighted that despite the recent developments in these processes, there is still a great deal of refinement to be made. EVs are produced by almost all cell types, found in many biological samples, and are implicated in multiple biological processes including cargo trafficking, cell-cell communication, and signal transduction. The presence of these EVs and their varied cargo in a biological sample can be indicative in disease diagnosis, and guide precision medicine-based approaches to disease management. EVs have been reported to actin the benefit of the cell through moderating repair and regeneration, but they can also act to the detriment of the cell through increased tumorigenesis and metastasis. This duality is intriguing as it can allow for the use of EVs in distinct therapeuticapproaches and displays their versatility in potential downstream applications. In this review, examples of the cellular roles of EVs and their applications in pathological and regenerative contexts are explored. In reviewing some of the developments madein recent times, EVs are shown to be very promising both in diagnostic and therapeutic approaches.

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Mining Exosomal Genes for Pancreatic Cancer Targets

Abstract: Abstract. Background: Exosomes, cell-

Cited by 22 publications

References 67 publications

Cellular Interactions in the Tumor Microenvironment: The Role of Secretome

Cellular Interactions in the Tumor Microenvironment: The Role of Secretome

In Vitro Elucidation of Drug Combination Synergy in Treatment of Pancreatic Ductal Adenocarcinoma

Origins to Outcomes: A Role for Extracellular Vesicles in Precision Medicine

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