Mining Prognostic Significance of MEG3 in Human Breast Cancer Using Bioinformatics Analysis

Cui, Xiangrong; Yi, Qiu; Xuan, Jianhua; Huang, Yue; Tian, Jie; Chen, Long; Xiang, Zhongping; Liu, Jianping; Zhang, Chunmin; Tan, Bin; Li, Yasha; Zhu, Jing

doi:10.1159/000493956

Cited by 39 publications

(35 citation statements)

References 40 publications

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“…Moreover, EPB41L4A-AS2 was also reported to inhibit proliferation and invasion and promote cell apoptosis in non-small cell lung cancer [39], in accordance with our results. Among the other identified lncRNAs, MEG3 was reported to suppress cell proliferation, invasion, and angiogenesis through the AKT pathway or the transcriptional activity of p53 in breast cancer [23–25, 40, 41]. LINC-PINT, which is regulated by p53, inhibits tumor cell invasion through a highly conserved sequence element [42, 43].…”

Section: Discussionmentioning

confidence: 99%

Landscape of tumor suppressor long noncoding RNAs in breast cancer

Pang

Wang

Ning

et al. 2019

J Exp Clin Cancer Res

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Background The landscape and biological functions of tumor suppressor long noncoding RNAs in breast cancer are still unknown. Methods Data from whole transcriptome sequencing of 33 breast specimens in the Harbin Medical University Cancer Center cohort and The Cancer Genome Atlas was applied to identify and validate the landscape of tumor suppressor long noncoding RNAs, which was further validated by The Cancer Genome Atlas pancancer data including 33 cancer types and 12,839 patients. Next, the expression model, prognostic roles, potential biological functions and epigenetic regulation of tumor suppressor long noncoding RNAs were investigated and validated in the breast cancer and pancancer cohorts. Finally, EPB41L4A-AS2 was selected to validate our novel finding, and the tumor suppressive roles of EPB41L4A-AS2 in breast cancer were examined. Results We identified and validated the landscape of tumor suppressor long noncoding RNAs in breast cancer. The expression of the identified long noncoding RNAs was downregulated in cancer tissue samples compared with normal tissue samples, and these long noncoding RNAs correlated with a favorable prognosis in breast cancer patients and the patients in the pancancer cohort. Multiple carcinogenesis-associated biological functions were predicted to be regulated negatively by these long noncoding RNAs. Moreover, these long noncoding RNAs were transcriptionally regulated by epigenetic modification, including DNA methylation and histone methylation modification. Finally, EPB41L4A-AS2 inhibited breast cancer cell proliferation, migration and invasion and induced cell apoptosis in vitro . Mechanistically, EPB41L4A-AS2, acting at least in part as a tumor suppressor, upregulated tumor suppressor gene expression. Moreover, ZNF217 recruited EZH2 to the EPB41L4A-AS2 locus and suppressed the expression of EPB41L4A-AS2 by epigenetically increasing H3K27me3 enrichment. Conclusions This work enlarges the functional landscape of known long noncoding RNAs in human cancer and provides novel insights into the suppressive roles of these long noncoding RNAs. Electronic supplementary material The online version of this article (10.1186/s13046-019-1096-0) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Landscape of tumor suppressor long noncoding RNAs in breast cancer

Pang

Wang

Ning

et al. 2019

J Exp Clin Cancer Res

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“…All available published SAGE data were applied to analyze SFTPC gene expression in human normal and malignant tissues. The analysis of Digital SFTPC gene expression profiles was analyzed and displayed with the SAGE Anatomic Viewer [28]. The Oncomine database, a publicly accessible online cancer microarray database containing 715 datasets and 86,733 samples, was searched to investigate the transcription level of the SFTPC gene in lung cancer [28].…”

Section: Bioinformatics Analysismentioning

confidence: 99%

“…The analysis of Digital SFTPC gene expression profiles was analyzed and displayed with the SAGE Anatomic Viewer [28]. The Oncomine database, a publicly accessible online cancer microarray database containing 715 datasets and 86,733 samples, was searched to investigate the transcription level of the SFTPC gene in lung cancer [28]. The data on the SFTPC mRNA expression (log2-transformed) in lung carcinoma and normal tissues were obtained from the Oncomine database and then were subjected to statistical comparison.…”

Section: Bioinformatics Analysismentioning

confidence: 99%

MiR-629-3p-induced downregulation of SFTPC promotes cell proliferation and predicts poor survival in lung adenocarcinoma

Meng

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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2019) MiR-629-3p-induced downregulation of SFTPC promotes cell proliferation and predicts poor survival in lung adenocarcinoma, Artificial Cells, Nanomedicine, and Biotechnology, 47:1, 3286-3296, ABSTRACTThe long-term prognosis of patients with lung cancer remains poor and thus it is imminent to further elucidate the molecular mechanism for the oncogenesis of lung cancer. In this study, we observed that surfactant protein C (SFTPC) expression was downregulated in human lung adenocarcinoma tissues and cell lines, and low SFTPC expression correlated with poor overall survival of lung adenocarcinoma patients. Moreover, we found that overexpression of SFTPC could inhibit lung cancer cell proliferation in vitro and in vivo, but downregulation of SFTPC showed the opposite results. Besides, it was observed that miR-629-3p expression was upregulated in human lung adenocarcinoma tissues and cell lines. More importantly, we found that miR-629-3p could downregulate SFTPC expression by directly binding to the SFTPC 3'-UTR and inhibit the regulatory effect of SFTPC on lung adenocarcinoma cell proliferation. In conclusion, these data suggested that miR-629-3p-meditated downregulation of SFTPC may promote lung adenocarcinoma progression. ARTICLE HISTORY

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“…Breast cancer is one of the most common malignancies and remains a leading cause of cancer-related deaths in the female worldwide 1 . The incidence of breast cancer is gradually increasing in most countries, including the United States 2 .…”

Section: Introductionmentioning

confidence: 99%

High Expression of Pseudogene PTTG3P Indicates a Poor Prognosis in Human Breast Cancer

Lou

Ding

Fan

2019

Molecular Therapy - Oncolytics

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Pseudogenes play pivotal roles in tumorigenesis. Previous studies have suggested that pituitary tumor-transforming 3, pseudogene (PTTG3P), serves as an oncogene in human cancers. However, its expression pattern, biological function, and underlying mechanism in breast cancer remain unknown. In this study, we demonstrated an elevated expression of PTTG3P in breast cancer and discovered that PTTG3P expression correlated negatively with estrogen receptor (ER) and progesterone receptor (PR) status, but linked positively to basal-like status, triplenegative breast cancer status, Nottingham prognostic index (NPI), and Scarff-Bloom-Richardson grade. High expression of PTTG3P was also found to be associated with a poor prognosis of breast cancer. To explore the potential mechanisms of PTTG3P, a PTTG3P-microRNA (miRNA)-mRNA regulatory network was established. Co-expressed genes of PTTG3P were also obtained. Enrichment analysis for these co-expressed genes revealed that they were significantly enriched in mitotic nuclear division and cell cycle. Subsequent research on mechanism of PTTG3P indicated that its expression correlated positively with PTTG1 expression. However, no significant expression correlation between PTTG3P and PTTG2 was observed. Taken together, our findings suggest that increased expression of pseudogene PTTG3P may be used as a promising prognostic biomarker and novel therapeutic target for breast cancer.

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Mining Prognostic Significance of MEG3 in Human Breast Cancer Using Bioinformatics Analysis

Cited by 39 publications

References 40 publications

Landscape of tumor suppressor long noncoding RNAs in breast cancer

Landscape of tumor suppressor long noncoding RNAs in breast cancer

MiR-629-3p-induced downregulation of SFTPC promotes cell proliferation and predicts poor survival in lung adenocarcinoma

High Expression of Pseudogene PTTG3P Indicates a Poor Prognosis in Human Breast Cancer

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