2021
DOI: 10.1371/journal.pone.0253918
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Mining the capacity of human-associated microorganisms to trigger rheumatoid arthritis—A systematic immunoinformatics analysis of T cell epitopes

Abstract: Autoimmune diseases, often triggered by infection, affect ~5% of the worldwide population. Rheumatoid Arthritis (RA)–a painful condition characterized by the chronic inflammation of joints—comprises up to 20% of known autoimmune pathologies, with the tendency of increasing prevalence. Molecular mimicry is recognized as the leading mechanism underlying infection-mediated autoimmunity, which assumes sequence similarity between microbial and self-peptides driving the activation of autoreactive lymphocytes. T lymp… Show more

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Cited by 12 publications
(8 citation statements)
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“…One of the most common hypotheses is that it involves infection with certain pathogenic microorganisms and subsequent molecular mimicry [ 1 , 2 , 3 , 4 , 5 ]. Molecular mimicry assumes sequence similarity between pathogenic and self-peptides that could provoke the cross-reactivity of the activated T or B cells to self-structures [ 6 ]. T lymphocytes (Th1 and Th17) are leading immune cells in the development of RA [ 6 , 7 , 8 ].…”
Section: Introductionmentioning
confidence: 99%
See 3 more Smart Citations
“…One of the most common hypotheses is that it involves infection with certain pathogenic microorganisms and subsequent molecular mimicry [ 1 , 2 , 3 , 4 , 5 ]. Molecular mimicry assumes sequence similarity between pathogenic and self-peptides that could provoke the cross-reactivity of the activated T or B cells to self-structures [ 6 ]. T lymphocytes (Th1 and Th17) are leading immune cells in the development of RA [ 6 , 7 , 8 ].…”
Section: Introductionmentioning
confidence: 99%
“…Molecular mimicry assumes sequence similarity between pathogenic and self-peptides that could provoke the cross-reactivity of the activated T or B cells to self-structures [ 6 ]. T lymphocytes (Th1 and Th17) are leading immune cells in the development of RA [ 6 , 7 , 8 ].…”
Section: Introductionmentioning
confidence: 99%
See 2 more Smart Citations
“…Affinity analyses have been widely used in the study of infectious diseases ( 22 24 ), neoplasms ( 25 ) and autoimmune diseases ( 26 ). Table 1 lists the current international mainstream epitope analysis algorithms.…”
Section: Introductionmentioning
confidence: 99%