Mining the Dark Matter of the Cancer Proteome for Novel Biomarkers

"Diabetes Associated Genes from the Dark Matter of the Human Proteome"

“…[9][10][11] In addition, the following genomewide association tools were used: the Genetic Association Database, GAD (31) 39 All of the bioinformatics mining was verified by two independent experiments. Big data was downloaded two independent times and the output verified for consistency.…”

“…Reasoning that such novel targets may emerge from characterizing the dark matter proteome, we have embarked on a systematic dissection of the uncharacterized proteins, the Open Reading Frames (ORFs) in the genome. [9][10][11] Our recent development of a cancer-associated fingerprint from the dark matter proteome, the OncoORFs, 11 provided a framework for expanding our approaches to other diseases.…”

Ebola-Associated Genes in the Human Genome: Implications for Novel Targets

“…In a series of recent reports our laboratory has demonstrated the diagnostic and therapy potential of these ORFs, termed the "Dark Matter" of the human proteome, in diverse therapeutic areas including cancer, diabetes and neurodegenerative diseases [25,26,40]. Hypothesizing that these novel proteins may offer new molecular entities to further Ebola virus research, a comprehensive analysis of the ORFs was undertaken (Table 2 Included as supplementary).…”

Neurodegenerative Diseases: Phenome to Genome Analysis

“…Targets relevant to cancer and diabetes were identified [21,22,48,54]. Reasoning that the 30 uncharacterized proteins, that showed strong genetic association with neurological diseases may offer novel biomarker and target potential, a comprehensive analysis was undertaken (Table 2 Included as supplementary).…”