Minipigs

Essential Role of Invasin for Colonization and Persistence of Yersinia enterocolitica in Its Natural Reservoir Host, the Pig

“…1B). Minimal to moderate inflammation of the lamina propria and submucosa of the small and large intestine is frequently observed in uninfected minipigs (33). In summary, we demonstrated that O:3 colonizes and persists in the lymphatic tissues of the tonsils and in the intestinal tracts of the minipigs, causing infections without severe inflammation and pathological changes, which is in accordance with natural infection in productive livestock.…”

“…However, these findings were frequently also seen in uninfected control pigs (see Fig. S1A and Table S1) (33).…”

A Brief Review of Infrequent Spontaneous Findings, Peculiar Anatomical Microscopic Features, and Potential Artifacts in Göttingen Minipigs

“…In the tongue, focal chondrocytes are occasionally observed, unassociated with inflammation ( Figure 15). The origin of the cartilage cells is thought to be ectopic (McInnes 2011). Cupping of the optic disk is often noted as a background finding in the minipig eye (Figure 16; McInnes 2011).…”

“…Ellipsoids are pale, eosinophilic structures arranged concentrically around capillaries or small arterioles in the spleen which may prove confusing to the novice pathologist ( Figure 12). The ellipsoids are prominent, consist of phagocytic cells and reticular fibers, and have been referred to in the literature as Schweigger-Seidel sheaths (Charles 1996;McInnes 2011). The perimesenteric plexus is a normal anatomical feature of the minipig mesenteric lymph nodes.…”

“…The vascular supply to the lymph nodes differs from that of other mammals. Major nodal arteries subdivide into branches that envelop the node as a capsular network from which further branches penetrate the parenchyma (McInnes 2011;Charles 1996). Foci of squamous epithelial metaplasia may be noted in the cuboidal epithelium of the salivary gland ducts (Figure 14; McInnes 2011).…”