Minisci-Type Dehydrogenative Coupling of N-Heteroaromatic Rings with Inert C(sp3)–H Enabled by a Visible-Light-Catalyzed Intermolecular Hydrogen Atom Transfer Process
Jun-Feng Yang,
Yun-Fei Liu,
Lin-Lin Wei
et al.
Abstract:The Minisci-type dehydrogenative coupling of N-heteroaromatic
rings
with inert C–H or Si–H partners via visible-light-catalyzed
hydrogen atom transfer has been reported. This methodology allows
the coupling reactions to be carried out in water as a solvent under
air atmospheric conditions with visible-light illumination. A wide
range of inert C–H and Si–H partners could be directly
coupled with various N-aromatic heterocycles to deliver products in
good to excellent yields.
Selective activation of inert and ubiquitous C(sp³)–H bonds has long been a challenging task in organic synthesis, through which chemists can directly synthesize value-added compounds from inexpensive and readily available...
Selective activation of inert and ubiquitous C(sp³)–H bonds has long been a challenging task in organic synthesis, through which chemists can directly synthesize value-added compounds from inexpensive and readily available...
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