Minitablets current use and future opportunities – An APV course on manufacturing, packaging, characterization and use of minitablets

Page, Susanne; Rode, Timo; Breitkreutz, Jörg; Wagner-Hattler, Leonie

doi:10.1016/j.ejpb.2024.114294

European Journal of Pharmaceutics and Biopharmaceutics

2024

DOI: 10.1016/j.ejpb.2024.114294

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Minitablets current use and future opportunities – An APV course on manufacturing, packaging, characterization and use of minitablets

Susanne Page,

Timo Rode,

Jörg Breitkreutz

et al.

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2024

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Utilization of the Drug–Polymer Solid Dispersion Obtained by Ball Milling as a Taste Masking Method in the Development of Orodispersible Minitablets with Hydrocortisone in Pediatric Doses

Trofimiuk,

Olechno,

Trofimiuk

et al. 2024

Pharmaceutics

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The objective of the conducted research was to design 2 mm orodispersible minitablets of pediatric doses of hydrocortisone (0.5 mg; 1.0 mg) with desirable pharmaceutical properties and eliminate the sensation of a bitter taste using preparation of solid dispersion by ball mill. Hydrocortisone was selected as the model substance, as it is widely utilized in the pediatric population. ODMTs were prepared by compression (preceded by granulation) in a traditional single-punch tablet machine and evaluated using pharmacopoeial tests, DSC, and FTIR analysis. The methods used to evaluate the effectiveness of the taste-masking effect included in vivo participation of healthy volunteers, in vitro drug dissolution and utilization of an analytical device—“electronic tongue”. The research employed a preclinical animal model to preliminary investigate the bioequivalence of the designed drug dosage form in comparison to reference products. The study confirmed the possibility of manufacturing good-quality hydrocortisone ODMTs with a taste-masking effect owing to the incorporation of a solid dispersion in the tablet mass.

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Utilization of the Drug–Polymer Solid Dispersion Obtained by Ball Milling as a Taste Masking Method in the Development of Orodispersible Minitablets with Hydrocortisone in Pediatric Doses

Trofimiuk,

Olechno,

Trofimiuk

et al. 2024

Pharmaceutics

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show abstract

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Minitablets current use and future opportunities – An APV course on manufacturing, packaging, characterization and use of minitablets

Cited by 1 publication

References 13 publications

Utilization of the Drug–Polymer Solid Dispersion Obtained by Ball Milling as a Taste Masking Method in the Development of Orodispersible Minitablets with Hydrocortisone in Pediatric Doses

Utilization of the Drug–Polymer Solid Dispersion Obtained by Ball Milling as a Taste Masking Method in the Development of Orodispersible Minitablets with Hydrocortisone in Pediatric Doses

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